pcn-1 Proliferating cell nuclear antigen [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Gene symbol: pcn-1
Gene description: Proliferating cell nuclear antigen
Primary source: WormBase:WBGene00003955
Locus tag: CELE_W03D2.4
See related: AllianceGenome:WB:WBGene00003955
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA polymerase binding activity. Predicted to be involved in leading strand elongation; mismatch repair; and translesion synthesis. Predicted to be located in nucleus. Predicted to be part of PCNA complex. Is expressed in germ line. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_003282.8 (4047937..4049448, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

roles of PCNA K165 modification during C. elegans gametogenesis and embryogenesis
Title: Vital roles of PCNA K165 modification during C. elegans gametogenesis and embryogenesis.
In the C. elegans early embryo as well as other organisms, PCN-1 accumulates in nuclei only during S-phase.
Title: Cell cycle accumulation of the proliferating cell nuclear antigen PCN-1 transitions from continuous in the adult germline to intermittent in the early embryo of C. elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

W03D2.4 (e-PCR)
- UniSTS:315150

STS4-15 (e-PCR)
- UniSTS:242139

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA polymerase processivity factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA polymerase processivity factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in leading strand elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of PCNA complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Proliferating cell nuclear antigen

NP_500466.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

4047937..4049448 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068065.10 → NP_500466.3 Proliferating cell nuclear antigen [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500466.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O02115

Conserved Domains (2) summary

cd00577
Location:4 → 257

PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...

TIGR00590
Location:1 → 260

pcna; proliferating cell nuclear antigen (pcna)