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    K11H3.3 Putative tricarboxylate transport protein, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 176398, updated on 23-Nov-2023

    Summary

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    Gene symbol
    K11H3.3
    Gene description
    Putative tricarboxylate transport protein, mitochondrial
    Primary source
    WormBase:WBGene00010780
    Locus tag
    CELE_K11H3.3
    See related
    AllianceGenome:WB:WBGene00010780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitochondrial citrate transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of membrane. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; combined D-2- and L-2-hydroxyglutaric aciduria; and congenital myasthenic syndrome. Orthologous to human SLC25A1 (solute carrier family 25 member 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (9851854..9853826)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ribosomal protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Glycerol-3-phosphate dehydrogenase [NAD(+)];putative glycerol-3-phosphate dehydrogenase 2 Neighboring gene Potassium channel domain-containing protein Neighboring gene tRNA-Ser Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables citrate secondary active transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial citrate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative tricarboxylate transport protein, mitochondrial
    NP_499187.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9851854..9853826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066786.6 → NP_499187.1  Putative tricarboxylate transport protein, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499187.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34519
      Conserved Domains (1) summary
      pfam00153
      Location:225 → 304
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34519.1

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