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    ZNF664 zinc finger protein 664 [ Homo sapiens (human) ]

    Gene ID: 144348, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF664provided by HGNC
    Official Full Name
    zinc finger protein 664provided by HGNC
    Primary source
    HGNC:HGNC:25406
    See related
    Ensembl:ENSG00000179195 MIM:617890; AllianceGenome:HGNC:25406
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFOC1; ZNF176
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 67.7), small intestine (RPKM 46.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12q24.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (123973215..124015427)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (123974731..124016943)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (124457762..124499974)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124422596-124423096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124423097-124423597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124438925-124439426 Neighboring gene NANOG hESC enhancer GRCh37_chr12:124453330-124453831 Neighboring gene dynein axonemal heavy chain 10 opposite strand Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124456125-124456862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124456863-124457600 Neighboring gene ZNF664-RFLNA readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5056 Neighboring gene coiled-coil domain containing 92 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7279 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:124556312-124557118 Neighboring gene NANOG hESC enhancer GRCh37_chr12:124594949-124595450 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124600014-124600560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124601106-124601651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124601652-124602196 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:124608857-124609358 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:124624781-124625523 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124625524-124626265 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:124630091-124630857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124666563-124667068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124672143-124672663 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124672664-124673183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124673184-124673704 Neighboring gene Sharpr-MPRA regulatory region 13038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124725860-124726762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7280 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124786919-124787420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124801665-124802264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7283 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:124821000-124821180 Neighboring gene refilin A Neighboring gene microRNA 6880 Neighboring gene nuclear receptor corepressor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Exome sequencing identifies ZNF644 mutations in high myopia. Shi Y, et al. PLoS Genet, 2011 Jun. PMID 21695231, Free PMC Article
    2. A novel zinc finger gene preferentially expressed in the retina and the organ of Corti localizes to human chromosome 12q24.3. Rivolta MN, et al. Biochim Biophys Acta, 1996 May 2. PMID 8634327
    3. Genome-wide association study identifies new disease loci for isolated clubfoot. Zhang TX, et al. J Med Genet, 2014 May. PMID 24667120
    4. A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2. Wu Y, et al. Hum Mol Genet, 2014 Feb 15. PMID 24105470, Free PMC Article
    5. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. Chasman DI, et al. PLoS Genet, 2009 Nov. PMID 19936222, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
    EBI GWAS Catalog
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study identifies new disease loci for isolated clubfoot.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough ZNF664-RFLNA

    Readthrough gene: ZNF664-RFLNA, Included gene: RFLNA

    Homology

    Clone Names

    • MGC126579, DKFZp761B128

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 664
    Names
    zinc finger Organ of Corti 1
    zinc finger protein 176
    zinc finger protein from organ of Corti

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204298.2 → NP_001191227.1  zinc finger protein 664

      See identical proteins and their annotated locations for NP_001191227.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC068790, BC051696, BQ185193, BX647762, DA328413
      Consensus CDS
      CCDS9257.1
      UniProtKB/Swiss-Prot
      B3KP97, Q15914, Q3ZCQ7, Q8N3J9
      Related
      ENSP00000376205.3, ENST00000392404.7
      Conserved Domains (3) summary
      COG5048
      Location:94 → 256
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:173 → 193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:74 → 97
      zf-H2C2_2; Zinc-finger double domain

    2. NM_152437.3 → NP_689650.1  zinc finger protein 664

      See identical proteins and their annotated locations for NP_689650.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC068790, AK056034, BC051696, BQ185193, BX647762, DA304849
      Consensus CDS
      CCDS9257.1
      UniProtKB/Swiss-Prot
      B3KP97, Q15914, Q3ZCQ7, Q8N3J9
      Related
      ENSP00000337320.4, ENST00000337815.9
      Conserved Domains (3) summary
      COG5048
      Location:94 → 256
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:173 → 193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:74 → 97
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      123973215..124015427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      123974731..124016943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N3J9.1 GenPept UniProtKB/Swiss-Prot:Q8N3J9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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