Cxcr4 C-X-C motif chemokine receptor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cxcr4provided by MGI
Official Full Name: C-X-C motif chemokine receptor 4provided by MGI
Primary source: MGI:MGI:109563
See related: Ensembl:ENSMUSG00000045382 AllianceGenome:MGI:109563
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD184; LESTR; Sdf1r; CXC-R4; CXCR-4; Cmkar4; PB-CKR; b2b220Clo; PBSF/SDF-1
Summary: Predicted to enable several functions, including chemokine receptor activity; cytoskeletal protein binding activity; and ubiquitin protein ligase binding activity. Involved in myelin maintenance; positive regulation of cold-induced thermogenesis; and positive regulation of oligodendrocyte differentiation. Acts upstream of or within several processes, including circulatory system development; gamete generation; and nervous system development. Located in cell-cell junction; external side of plasma membrane; and growth cone. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; extraembryonic component; and nervous system. Used to study WHIM syndrome. Human ortholog(s) of this gene implicated in WHIM syndrome; hematologic cancer (multiple); leukopenia; osteoporosis; and pancreatic adenocarcinoma. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 230.6), spleen adult (RPKM 93.9) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 56.43 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (128515936..128520036, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (128588199..128592299, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synthetic biology-based bacterial extracellular vesicles displaying BMP-2 and CXCR4 to ameliorate osteoporosis.
Title: Synthetic biology-based bacterial extracellular vesicles displaying BMP-2 and CXCR4 to ameliorate osteoporosis.
CXCL12-CXCR4 mediates CD57[+] CD8[+] T cell responses in the progression of type 1 diabetes.
Title: CXCL12-CXCR4 mediates CD57(+) CD8(+) T cell responses in the progression of type 1 diabetes.
Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B Cells.
Title: Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B Cells.
C-X-C chemokine receptor type 4 promotes tubular cell senescence and renal fibrosis through beta-catenin-inhibited fatty acid oxidation.
Title: C-X-C chemokine receptor type 4 promotes tubular cell senescence and renal fibrosis through β-catenin-inhibited fatty acid oxidation.
The CXCR4-AT1 axis plays a vital role in glomerular injury via mediating the crosstalk between podocyte and mesangial cell.
Title: The CXCR4-AT1 axis plays a vital role in glomerular injury via mediating the crosstalk between podocyte and mesangial cell.
Study of the Effect of Wild-Type and Transiently Expressing CXCR4 and IL-10 Mesenchymal Stromal Cells in a Mouse Model of Peritonitis.
Title: Study of the Effect of Wild-Type and Transiently Expressing CXCR4 and IL-10 Mesenchymal Stromal Cells in a Mouse Model of Peritonitis.
CXCR4-overexpressed exosomes from cardiosphere-derived cells attenuate myocardial ischemia/reperfusion injury by transferring miRNA to macrophages and regulating macrophage polarization.
Title: CXCR4-overexpressed exosomes from cardiosphere-derived cells attenuate myocardial ischemia/reperfusion injury by transferring miRNA to macrophages and regulating macrophage polarization.
Maternal CXCR4 deletion results in placental defects and pregnancy loss mediated by immune dysregulation.
Title: Maternal CXCR4 deletion results in placental defects and pregnancy loss mediated by immune dysregulation.
PFKFB3 promotes sepsis-induced acute lung injury by enhancing NET formation by CXCR4[hi] neutrophils.
Title: PFKFB3 promotes sepsis-induced acute lung injury by enhancing NET formation by CXCR4(hi) neutrophils.
CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in preclinical breast cancer model.
Title: CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in preclinical breast cancer model.

Submit: New GeneRIF Correction See all GeneRIFs (403)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC310750P1 (e-PCR)
- UniSTS:272668

Cmkar4 (e-PCR), detects polymorphism
- UniSTS:141356

Cxcr4 (e-PCR), detects polymorphism
- UniSTS:464706

PMC151816P1 (e-PCR)
- UniSTS:271182

Cxcr4 (e-PCR), detects polymorphism
- UniSTS:525664

Cxcr4 (e-PCR), detects polymorphism
- UniSTS:463203

PMC124533P1 (e-PCR)
- UniSTS:270473

Cxcr4 (e-PCR), detects polymorphism
- UniSTS:528302

PMC154343P1 (e-PCR)
- UniSTS:271307

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-X-C motif chemokine 12 receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables cytokine binding	IEA Inferred from Electronic Annotation more info
enables myosin light chain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small molecule binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CXCL12-activated CXCR4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in CXCL12-activated CXCR4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium-mediated signaling	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organonitrogen compound	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in detection of mechanical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in endothelial tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell development	ISO Inferred from Sequence Orthology more info
involved_in generation of neurons	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myelin maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in neural precursor cell proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of calcium ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage migration inhibitory factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal stem cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular wound healing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasculature development	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in regulation of viral process	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in response to tacrolimus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in telencephalon cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
colocalizes_with early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
colocalizes_with lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-X-C chemokine receptor type 4

Names: SDF-1 receptor; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C) receptor 4; chemokine receptor 4; fusin; leukocyte-derived seven transmembrane domain receptor; leukocyte-expressed seven-transmembrane-domain; pre-B-cell-derived chemokine receptor; stromal cell-derived factor 1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356509.1 → NP_001343438.1 C-X-C chemokine receptor type 4 isoform 2

Status: VALIDATED

Source sequence(s)

AC161170

UniProtKB/Swiss-Prot

O09059, O09062, P70233, P70346, P70658, Q4KMW1

Conserved Domains (2) summary

pfam12109
Location:6 → 38

CXCR4_N; CXCR4 Chemokine receptor N terminal

cd15179
Location:39 → 318

7tmA_CXCR4; CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001420067.1 → NP_001406996.1 C-X-C chemokine receptor type 4 isoform 3

Status: VALIDATED

Source sequence(s)

AC161170
NM_001420068.1 → NP_001406997.1 C-X-C chemokine receptor type 4 isoform 3

Status: VALIDATED

Source sequence(s)

AC161170
NM_009911.4 → NP_034041.2 C-X-C chemokine receptor type 4 isoform 1

See identical proteins and their annotated locations for NP_034041.2

Status: VALIDATED

Source sequence(s)

AC161170

Consensus CDS

CCDS15254.1

UniProtKB/Swiss-Prot

O09059, O09062, P70233, P70346, P70658, Q4KMW1

UniProtKB/TrEMBL

A0A0R4J0N8

Related

ENSMUSP00000053489.7, ENSMUST00000052172.7

Conserved Domains (2) summary

pfam00001
Location:57 → 309

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam12109
Location:8 → 40

CXCR4_N; CXCR4 Chemokine receptor N terminal