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    TMED7-TICAM2 TMED7-TICAM2 readthrough [ Homo sapiens (human) ]

    Gene ID: 100302736, updated on 8-Mar-2024

    Summary

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    Official Symbol
    TMED7-TICAM2provided by HGNC
    Official Full Name
    TMED7-TICAM2 readthroughprovided by HGNC
    Primary source
    HGNC:HGNC:33945
    See related
    Ensembl:ENSG00000251201 AllianceGenome:HGNC:33945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIRP; TRAM; TICAM2; TIRAP3; MyD88-4; TICAM-2
    Summary
    This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]
    Expression
    Ubiquitous expression in endometrium (RPKM 26.4), prostate (RPKM 21.6) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    5q22.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (115578496..115626036, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (116091278..116138818, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (114914193..114961733, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 5 pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114880021-114880787 Neighboring gene fem-1 homolog C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16252 Neighboring gene TIR domain containing adaptor molecule 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114937526-114938048 Neighboring gene TICAM2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22936 Neighboring gene transmembrane p24 trafficking protein 7 Neighboring gene uncharacterized LOC102467217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:115010104-115010604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:115010605-115011105 Neighboring gene uncharacterized LOC124901048

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. Palsson-McDermott EM, et al. Nat Immunol, 2009 Jun. PMID 19412184
    2. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. Bin LH, et al. J Biol Chem, 2003 Jul 4. PMID 12721283
    3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
    4. The N(6)-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2. Li B, et al. Theranostics, 2022. PMID 36168628, Free PMC Article
    5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ90737

    General protein information

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    Preferred Names
    TRAM adaptor with GOLD domain
    Names
    Putative NF-kappa-B-activating protein 502
    TIR domain-containing adapter molecule 2
    TMED7-TICAM2 read-through transcript
    Toll-like receptor adaptor protein 3
    Toll/interleukin-1 receptor domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164468.4 → NP_001157940.1  TRAM adaptor with GOLD domain isoform 1 precursor

      See identical proteins and their annotated locations for NP_001157940.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1), also known as TAG. This isoform shares sequence identity with the products of both the TMED7 and TICAM2 genes.
      Source sequence(s)
      AC010226, AY304584
      UniProtKB/Swiss-Prot
      Q86XR7
      Related
      ENSP00000282382.4, ENST00000282382.8
      Conserved Domains (2) summary
      pfam01105
      Location:36 → 189
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD
      cl23749
      Location:250 → 341
      TIR_2; TIR domain

    2. NM_001164469.4 → NP_001157941.1  TRAM adaptor with GOLD domain isoform 2 precursor

      See identical proteins and their annotated locations for NP_001157941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site that causes an early stop codon in the 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus and shares no sequence identity with the downstream TICAM2 gene product, compared to isoform 1.
      Source sequence(s)
      AC010226, AY304583
      UniProtKB/TrEMBL
      A0A0A6YYA0
      Related
      ENSP00000333650.3, ENST00000333314.3
      Conserved Domains (1) summary
      pfam01105
      Location:36 → 188
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      115578496..115626036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      116091278..116138818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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