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CCNG1 cyclin G1 [ Homo sapiens (human) ]

Gene ID: 900, updated on 5-Mar-2024

Summary

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Official Symbol
CCNG1provided by HGNC
Official Full Name
cyclin G1provided by HGNC
Primary source
HGNC:HGNC:1592
See related
Ensembl:ENSG00000113328 MIM:601578; AllianceGenome:HGNC:1592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCNG
Summary
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 74.2), small intestine (RPKM 61.6) and 25 other tissues See more
Orthologs
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Genomic context

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See CCNG1 in Genome Data Viewer
Location:
5q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (163437571..163457640)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (163972739..163983375)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (162864577..162875205)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L57 pseudogene 6 Neighboring gene uncharacterized LOC105377700 Neighboring gene NANOG hESC enhancer GRCh37_chr5:162605640-162606379 Neighboring gene uncharacterized LOC124901125 Neighboring gene MPRA-validated peak5562 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:162756879-162757856 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:162757857-162758834 Neighboring gene NANOG hESC enhancer GRCh37_chr5:162800374-162800875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23575 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16589 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:162864697-162865274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16590 Neighboring gene NudC domain containing 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:162929934-162930742 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:162932358-162933164 Neighboring gene HMMR antisense RNA 1 Neighboring gene hyaluronan mediated motility receptor Neighboring gene methionine adenosyltransferase 2 non-catalytic beta subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Effects of expression of exogenous cyclin G1 on proliferation of human endometrial carcinoma cells. Liu F, et al. Chin J Physiol, 2013 Apr 30. PMID 23589924
  2. The role of progesterone and its receptor on cyclin G1 expression in endometrial carcinoma cells. Liu F, et al. Reprod Sci, 2012 Nov. PMID 22649121
  3. The negative role of cyclin G in ATM-dependent p53 activation. Ohtsuka T, et al. Oncogene, 2004 Jul 8. PMID 15077171
  4. Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells. Reimer CL, et al. J Biol Chem, 1999 Apr 16. PMID 10196184
  5. Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing Apoptosis. Xu G, et al. Radiat Res, 2021 Apr 1. PMID 33543294

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1.
    Title: PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1.
  2. Long noncoding RNA OIP5AS1 facilitates the progression of ovarian cancer via the miR1283p/CCNG1 axis.
    Title: Long non‑coding RNA OIP5‑AS1 facilitates the progression of ovarian cancer via the miR‑128‑3p/CCNG1 axis.
  3. Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing Apoptosis.
    Title: Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing Apoptosis.
  4. MicroRNA-488 inhibits ovarian cancer cell metastasis through regulating CCNG1 and p53 expression.
    Title: MicroRNA-488 inhibits ovarian cancer cell metastasis through regulating CCNG1 and p53 expression.
  5. MicroRNA-23a inhibits the growth of papillary thyroid carcinoma via regulating cyclin G1.
    Title: MicroRNA-23a inhibits the growth of papillary thyroid carcinoma via regulating cyclin G1.
  6. Methylation-associated miR-9 down-regulation is probably one of the key mechanisms for paclitaxel resistance in EOC cells, via targeting CCNG1.
    Title: Methylation-associated Has-miR-9 deregulation in paclitaxel- resistant epithelial ovarian carcinoma.
  7. Our findings indicate that CCNG1 overexpression, which is associated with poor clinical prognosis of high-grade serous ovarian cancer(HGSOC), can promote metastasis and chemotherapy resistance via the P53mt-Notch3 pathway. Our data also suggest that CCNG1 inhibitors represent a novel approach to increase chemotherapy efficacy in HGSOC and potentially improve patient outcomes.
    Title: CCNG1 (Cyclin G1) regulation by mutant-P53 via induction of Notch3 expression promotes high-grade serous ovarian cancer (HGSOC) tumorigenesis and progression.
  8. Cyclin G1 (CG1), an atypical cyclin, promoted G2-M arrest in proximal tubular cell and up-regulated target of rapamycin (TOR)-autophagy spatial coupling compartment formation.
    Title: Cyclin G1 and TASCC regulate kidney epithelial cell G(2)-M arrest and fibrotic maladaptive repair.
  9. our findings revealed that the C/EBPbeta-LINC01133 axis performs an oncogenic function in pancreatic ductal adenocarcinoma by activating CCNG1
    Title: The C/EBPβ-LINC01133 axis promotes cell proliferation in pancreatic ductal adenocarcinoma through upregulation of CCNG1.
  10. miR-516b functions as a tumor suppressor by directly modulating CCNG1 expression in esophageal squamous carcinoma cells.
    Title: miR-516b functions as a tumor suppressor by directly modulating CCNG1 expression in esophageal squamous cell carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to gravity IEA
Inferred from Electronic Annotation
more info
  
involved_in response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
  
involved_in syncytium formation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin-G1
Names
cyclin-G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364015.1 → NP_001350944.1  cyclin-G1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Consensus CDS
    CCDS4360.1
    UniProtKB/Swiss-Prot
    B2R7B2, B4DLW7, D3DQK7, P51959, Q15757, Q96L32
    Conserved Domains (1) summary
    cd20583
    Location:51 → 148
    CYCLIN_CCNG1; cyclin box found in cyclin-G1 (CCNG1) and similar proteins

  2. NM_001364018.1 → NP_001350947.1  cyclin-G1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Conserved Domains (1) summary
    pfam00134
    Location:20 → 149
    Cyclin_N; Cyclin, N-terminal domain

  3. NM_001364019.1 → NP_001350948.1  cyclin-G1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Conserved Domains (1) summary
    pfam00134
    Location:20 → 149
    Cyclin_N; Cyclin, N-terminal domain

  4. NM_001364020.1 → NP_001350949.1  cyclin-G1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Conserved Domains (1) summary
    pfam00134
    Location:20 → 149
    Cyclin_N; Cyclin, N-terminal domain

  5. NM_001364021.1 → NP_001350950.1  cyclin-G1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Conserved Domains (1) summary
    cl00050
    Location:30 → 91
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

  6. NM_001364022.1 → NP_001350951.1  cyclin-G1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Consensus CDS
    CCDS93817.1
    UniProtKB/TrEMBL
    E7ERZ1
    Related
    ENSP00000424315.1, ENST00000512163.5

  7. NM_001364023.1 → NP_001350952.1  cyclin-G1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Consensus CDS
    CCDS93817.1
    UniProtKB/TrEMBL
    E7ERZ1

  8. NM_004060.4 → NP_004051.1  cyclin-G1 isoform a

    See identical proteins and their annotated locations for NP_004051.1

    Status: REVIEWED

    Source sequence(s)
    BC000196, BX644635
    Consensus CDS
    CCDS4360.1
    UniProtKB/Swiss-Prot
    B2R7B2, B4DLW7, D3DQK7, P51959, Q15757, Q96L32
    Related
    ENSP00000344635.2, ENST00000340828.7
    Conserved Domains (1) summary
    cd20583
    Location:51 → 148
    CYCLIN_CCNG1; cyclin box found in cyclin-G1 (CCNG1) and similar proteins

  9. NM_199246.2 → NP_954854.1  cyclin-G1 isoform a

    See identical proteins and their annotated locations for NP_954854.1

    Status: REVIEWED

    Source sequence(s)
    BC000196, BM479568
    Consensus CDS
    CCDS4360.1
    UniProtKB/Swiss-Prot
    B2R7B2, B4DLW7, D3DQK7, P51959, Q15757, Q96L32
    Conserved Domains (1) summary
    cd20583
    Location:51 → 148
    CYCLIN_CCNG1; cyclin box found in cyclin-G1 (CCNG1) and similar proteins

RNA

  1. NR_157051.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205, BX538035

  2. NR_157052.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205

  3. NR_157053.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205

  4. NR_157054.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205

  5. NR_157055.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205

  6. NR_157056.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    163437571..163457640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417862.1 → XP_047273818.1  cyclin-G1 isoform X1

RNA

  1. XR_007058657.1 RNA Sequence

  2. XR_007058655.1 RNA Sequence

  3. XR_007058656.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    163972739..163983375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353746.1 → XP_054209721.1  cyclin-G1 isoform X1

RNA

  1. XR_008487192.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51959.2 GenPept UniProtKB/Swiss-Prot:P51959

Gene LinkOut

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