U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MYO9A myosin IXA [ Homo sapiens (human) ]

Gene ID: 4649, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
MYO9Aprovided by HGNC
Official Full Name
myosin IXAprovided by HGNC
Primary source
HGNC:HGNC:7608
See related
Ensembl:ENSG00000066933 MIM:604875; AllianceGenome:HGNC:7608
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMS24
Summary
This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]
Expression
Broad expression in testis (RPKM 12.9), thyroid (RPKM 5.9) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
15q23
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (71822291..72118600, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (69641241..69935336, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (72114632..72410491, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene thrombospondin type 1 domain containing 4 Neighboring gene THSD4 antisense RNA 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:72053567-72054766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9705 Neighboring gene Sharpr-MPRA regulatory region 1602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9709 Neighboring gene RNA, 5S ribosomal pseudogene 399 Neighboring gene nuclear receptor subfamily 2 group E member 3 Neighboring gene uncharacterized LOC107984713 Neighboring gene uncharacterized LOC107984714 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:72323133-72323348 Neighboring gene eukaryotic translation initiation factor 5A2 pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:72394409-72394919 Neighboring gene RNA, U2 small nuclear 65, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9712 Neighboring gene uncharacterized LOC124903522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9713 Neighboring gene Sharpr-MPRA regulatory region 4122 Neighboring gene ribosomal protein L21 pseudogene 115 Neighboring gene SUMO peptidase family member, NEDD8 specific Neighboring gene GRAM domain containing 2A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Self-organization of actin networks by a monomeric myosin. Saczko-Brack D, et al. Proc Natl Acad Sci U S A, 2016 Dec 27. PMID 27956608, Free PMC Article
  2. Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions. Omelchenko T, et al. Curr Biol, 2012 Feb 21. PMID 22305756, Free PMC Article
  3. Class IX Myosins: Motorized RhoGAP Signaling Molecules. Hanley PJ, et al. Adv Exp Med Biol, 2020. PMID 32451867
  4. The cloning and developmental expression of unconventional myosin IXA (MYO9A) a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23. Gorman SW, et al. Genomics, 1999 Jul 15. PMID 10409426
  5. Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis. Li Q, et al. Kidney Int, 2021 May. PMID 33412162, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis.
    Title: Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis.
  2. Class IX Myosins: Motorized RhoGAP Signaling Molecules.
    Title: Class IX Myosins: Motorized RhoGAP Signaling Molecules.
  3. analysis of actin network self-organization by a monomeric myosin IXa
    Title: Self-organization of actin networks by a monomeric myosin.
  4. MYO9A deficiency may affect the presynaptic motor axon, manifesting in congenital myasthenic syndrome.
    Title: Identification of mutations in the MYO9A gene in patients with congenital myasthenic syndrome.
  5. Vaccinia virus F11 promotes viral spread by binding to host myosin-9A and inhibit RhoA signaling.
    Title: Vaccinia virus F11 promotes viral spread by acting as a PDZ-containing scaffolding protein to bind myosin-9A and inhibit RhoA signaling.
  6. Depletion of myosin-IXA in collectively migrating cells led to altered organization of the actin cytoskeleton and tension-dependent disruption of cell-cell adhesions, followed by an inability to form new adhesions resulting in cell scattering.
    Title: Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Congenital myasthenic syndrome
MedGen: C0751882 GeneReviews: Congenital Myasthenic Syndromes Overview
Compare labs
Myasthenic syndrome, congenital, 24, presynaptic
MedGen: C4748684 OMIM: 618198 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ11061, FLJ13244, MGC71859

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity TAS
Traceable Author Statement
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neuron projection arborization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
  
involved_in visual perception TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in axonal growth cone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axonal growth cone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
part_of unconventional myosin complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
unconventional myosin-IXa
Names
myosin-IXa
unconventional myosin-9a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006901.4 → NP_008832.2  unconventional myosin-IXa

    See identical proteins and their annotated locations for NP_008832.2

    Status: REVIEWED

    Source sequence(s)
    AC020779, AC022872, AC104938, AF117888, BC060886, BC140869, BC150294, DB100556
    Consensus CDS
    CCDS10239.1
    UniProtKB/Swiss-Prot
    B0I1T5, B2RTY4, C9IYB3, C9JA86, Q14787, Q3YLD7, Q3YLD8, Q6P986, Q9H8T5, Q9NTG2, Q9NUY2, Q9UEP3, Q9UNJ2
    UniProtKB/TrEMBL
    A0A2X0SFG5
    Related
    ENSP00000348349.5, ENST00000356056.10
    Conserved Domains (5) summary
    smart00242
    Location:143 → 1014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:2000 → 2048
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:2061 → 2246
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160 → 1004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6 → 110
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    71822291..72118600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432576.1 → XP_047288532.1  unconventional myosin-IXa isoform X14

  2. XM_047432553.1 → XP_047288509.1  unconventional myosin-IXa isoform X5

  3. XM_047432585.1 → XP_047288541.1  unconventional myosin-IXa isoform X20

  4. XM_047432571.1 → XP_047288527.1  unconventional myosin-IXa isoform X12

  5. XM_047432556.1 → XP_047288512.1  unconventional myosin-IXa isoform X6

  6. XM_047432578.1 → XP_047288534.1  unconventional myosin-IXa isoform X16

    UniProtKB/Swiss-Prot
    B0I1T5, B2RTY4, C9IYB3, C9JA86, Q14787, Q3YLD7, Q3YLD8, Q6P986, Q9H8T5, Q9NTG2, Q9NUY2, Q9UEP3, Q9UNJ2

  7. XM_011521615.4 → XP_011519917.1  unconventional myosin-IXa isoform X1

    See identical proteins and their annotated locations for XP_011519917.1

    UniProtKB/TrEMBL
    A0A2X0SFG5
    Conserved Domains (5) summary
    smart00242
    Location:143 → 1014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:2072 → 2120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:2133 → 2318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160 → 1004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6 → 110
    UBQ; Ubiquitin-like proteins

  8. XM_047432573.1 → XP_047288529.1  unconventional myosin-IXa isoform X13

  9. XM_047432569.1 → XP_047288525.1  unconventional myosin-IXa isoform X12

  10. XM_047432580.1 → XP_047288536.1  unconventional myosin-IXa isoform X17

  11. XM_047432559.1 → XP_047288515.1  unconventional myosin-IXa isoform X8

  12. XM_047432554.1 → XP_047288510.1  unconventional myosin-IXa isoform X6

  13. XM_047432551.1 → XP_047288507.1  unconventional myosin-IXa isoform X5

  14. XM_047432584.1 → XP_047288540.1  unconventional myosin-IXa isoform X19

  15. XM_047432565.1 → XP_047288521.1  unconventional myosin-IXa isoform X10

  16. XM_047432561.1 → XP_047288517.1  unconventional myosin-IXa isoform X9

  17. XM_047432575.1 → XP_047288531.1  unconventional myosin-IXa isoform X14

  18. XM_047432549.1 → XP_047288505.1  unconventional myosin-IXa isoform X4

  19. XM_047432547.1 → XP_047288503.1  unconventional myosin-IXa isoform X2

  20. XM_011521616.4 → XP_011519918.1  unconventional myosin-IXa isoform X1

    See identical proteins and their annotated locations for XP_011519918.1

    UniProtKB/TrEMBL
    A0A2X0SFG5
    Conserved Domains (5) summary
    smart00242
    Location:143 → 1014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:2072 → 2120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:2133 → 2318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160 → 1004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6 → 110
    UBQ; Ubiquitin-like proteins

  21. XM_047432577.1 → XP_047288533.1  unconventional myosin-IXa isoform X15

  22. XM_047432572.1 → XP_047288528.1  unconventional myosin-IXa isoform X13

  23. XM_047432568.1 → XP_047288524.1  unconventional myosin-IXa isoform X12

  24. XM_047432581.1 → XP_047288537.1  unconventional myosin-IXa isoform X18

  25. XM_017022230.3 → XP_016877719.1  unconventional myosin-IXa isoform X17

    UniProtKB/TrEMBL
    A0A2X0SFG5

  26. XM_047432558.1 → XP_047288514.1  unconventional myosin-IXa isoform X8

  27. XM_011521620.4 → XP_011519922.1  unconventional myosin-IXa isoform X6

    UniProtKB/TrEMBL
    A0A2X0SFG5
    Conserved Domains (5) summary
    smart00242
    Location:143 → 995
    MYSc; Myosin. Large ATPases
    cd00029
    Location:2052 → 2100
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:2113 → 2298
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160 → 985
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6 → 110
    UBQ; Ubiquitin-like proteins

  28. XM_047432557.1 → XP_047288513.1  unconventional myosin-IXa isoform X7

  29. XM_011521619.4 → XP_011519921.1  unconventional myosin-IXa isoform X5

    UniProtKB/TrEMBL
    A0A2X0SFG5
    Conserved Domains (5) summary
    smart00242
    Location:143 → 995
    MYSc; Myosin. Large ATPases
    cd00029
    Location:2053 → 2101
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:2114 → 2299
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160 → 985
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6 → 110
    UBQ; Ubiquitin-like proteins

  30. XM_047432583.1 → XP_047288539.1  unconventional myosin-IXa isoform X19

  31. XM_047432567.1 → XP_047288523.1  unconventional myosin-IXa isoform X11

  32. XM_047432564.1 → XP_047288520.1  unconventional myosin-IXa isoform X10

  33. XM_011521621.4 → XP_011519923.1  unconventional myosin-IXa isoform X9

    UniProtKB/TrEMBL
    A0A2X0SFG5
    Conserved Domains (5) summary
    smart00242
    Location:143 → 974
    MYSc; Myosin. Large ATPases
    cd00029
    Location:2032 → 2080
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:2093 → 2278
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160 → 964
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6 → 110
    UBQ; Ubiquitin-like proteins

  34. XM_011521622.4 → XP_011519924.1  unconventional myosin-IXa isoform X14

    UniProtKB/TrEMBL
    A0A2X0SFG5
    Conserved Domains (5) summary
    smart00242
    Location:143 → 1014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:2000 → 2048
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:2061 → 2246
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160 → 1004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6 → 110
    UBQ; Ubiquitin-like proteins

  35. XM_006720539.4 → XP_006720602.1  unconventional myosin-IXa isoform X4

    UniProtKB/TrEMBL
    A0A2X0SFG5
    Conserved Domains (5) summary
    smart00242
    Location:143 → 1014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:2071 → 2119
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:2132 → 2317
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160 → 1004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6 → 110
    UBQ; Ubiquitin-like proteins

  36. XM_011521617.4 → XP_011519919.1  unconventional myosin-IXa isoform X2

    UniProtKB/TrEMBL
    A0A2X0SFG5
    Conserved Domains (5) summary
    smart00242
    Location:143 → 1014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:2071 → 2119
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:2132 → 2317
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160 → 1004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6 → 110
    UBQ; Ubiquitin-like proteins

  37. XM_011521618.4 → XP_011519920.1  unconventional myosin-IXa isoform X3

    UniProtKB/TrEMBL
    A0A2X0SFG5
    Conserved Domains (5) summary
    smart00242
    Location:143 → 1014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:2072 → 2120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:2133 → 2318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160 → 1004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6 → 110
    UBQ; Ubiquitin-like proteins

  38. XM_011521613.4 → XP_011519915.1  unconventional myosin-IXa isoform X1

    See identical proteins and their annotated locations for XP_011519915.1

    UniProtKB/TrEMBL
    A0A2X0SFG5
    Conserved Domains (5) summary
    smart00242
    Location:143 → 1014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:2072 → 2120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:2133 → 2318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160 → 1004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6 → 110
    UBQ; Ubiquitin-like proteins

  39. XM_047432570.1 → XP_047288526.1  unconventional myosin-IXa isoform X12

  40. XM_047432579.1 → XP_047288535.1  unconventional myosin-IXa isoform X17

  41. XM_047432560.1 → XP_047288516.1  unconventional myosin-IXa isoform X8

  42. XM_047432555.1 → XP_047288511.1  unconventional myosin-IXa isoform X6

  43. XM_047432552.1 → XP_047288508.1  unconventional myosin-IXa isoform X5

  44. XM_047432566.1 → XP_047288522.1  unconventional myosin-IXa isoform X10

  45. XM_047432562.1 → XP_047288518.1  unconventional myosin-IXa isoform X9

  46. XM_017022229.2 → XP_016877718.1  unconventional myosin-IXa isoform X14

    UniProtKB/TrEMBL
    A0A2X0SFG5
    Conserved Domains (5) summary
    smart00242
    Location:143 → 1014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:2000 → 2048
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:2061 → 2246
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160 → 1004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6 → 110
    UBQ; Ubiquitin-like proteins

  47. XM_047432550.1 → XP_047288506.1  unconventional myosin-IXa isoform X4

  48. XM_047432548.1 → XP_047288504.1  unconventional myosin-IXa isoform X2

  49. XM_011521614.4 → XP_011519916.1  unconventional myosin-IXa isoform X1

    See identical proteins and their annotated locations for XP_011519916.1

    UniProtKB/TrEMBL
    A0A2X0SFG5
    Conserved Domains (5) summary
    smart00242
    Location:143 → 1014
    MYSc; Myosin. Large ATPases
    cd00029
    Location:2072 → 2120
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04377
    Location:2133 → 2318
    RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160 → 1004
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:6 → 110
    UBQ; Ubiquitin-like proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    69641241..69935336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378013.1 → XP_054233988.1  unconventional myosin-IXa isoform X14

  2. XM_054377988.1 → XP_054233963.1  unconventional myosin-IXa isoform X5

  3. XM_054378022.1 → XP_054233997.1  unconventional myosin-IXa isoform X20

  4. XM_054378007.1 → XP_054233982.1  unconventional myosin-IXa isoform X12

  5. XM_054377991.1 → XP_054233966.1  unconventional myosin-IXa isoform X6

  6. XM_054378015.1 → XP_054233990.1  unconventional myosin-IXa isoform X16

  7. XM_054377977.1 → XP_054233952.1  unconventional myosin-IXa isoform X1

  8. XM_054378009.1 → XP_054233984.1  unconventional myosin-IXa isoform X13

  9. XM_054378005.1 → XP_054233980.1  unconventional myosin-IXa isoform X12

  10. XM_054378018.1 → XP_054233993.1  unconventional myosin-IXa isoform X17

  11. XM_054377995.1 → XP_054233970.1  unconventional myosin-IXa isoform X8

  12. XM_054377989.1 → XP_054233964.1  unconventional myosin-IXa isoform X6

  13. XM_054377986.1 → XP_054233961.1  unconventional myosin-IXa isoform X5

  14. XM_054378021.1 → XP_054233996.1  unconventional myosin-IXa isoform X19

  15. XM_054378000.1 → XP_054233975.1  unconventional myosin-IXa isoform X10

  16. XM_054377998.1 → XP_054233973.1  unconventional myosin-IXa isoform X9

  17. XM_054378011.1 → XP_054233986.1  unconventional myosin-IXa isoform X14

  18. XM_054377983.1 → XP_054233958.1  unconventional myosin-IXa isoform X4

  19. XM_054377979.1 → XP_054233954.1  unconventional myosin-IXa isoform X2

  20. XM_054377975.1 → XP_054233950.1  unconventional myosin-IXa isoform X1

  21. XM_054378014.1 → XP_054233989.1  unconventional myosin-IXa isoform X15

  22. XM_054378008.1 → XP_054233983.1  unconventional myosin-IXa isoform X13

  23. XM_054378004.1 → XP_054233979.1  unconventional myosin-IXa isoform X12

  24. XM_054378019.1 → XP_054233994.1  unconventional myosin-IXa isoform X18

  25. XM_054378016.1 → XP_054233991.1  unconventional myosin-IXa isoform X17

  26. XM_054377994.1 → XP_054233969.1  unconventional myosin-IXa isoform X8

  27. XM_054377992.1 → XP_054233967.1  unconventional myosin-IXa isoform X6

  28. XM_054377993.1 → XP_054233968.1  unconventional myosin-IXa isoform X7

  29. XM_054377985.1 → XP_054233960.1  unconventional myosin-IXa isoform X5

  30. XM_054378020.1 → XP_054233995.1  unconventional myosin-IXa isoform X19

  31. XM_054378003.1 → XP_054233978.1  unconventional myosin-IXa isoform X11

  32. XM_054378002.1 → XP_054233977.1  unconventional myosin-IXa isoform X10

  33. XM_054377997.1 → XP_054233972.1  unconventional myosin-IXa isoform X9

  34. XM_054378010.1 → XP_054233985.1  unconventional myosin-IXa isoform X14

  35. XM_054377982.1 → XP_054233957.1  unconventional myosin-IXa isoform X4

  36. XM_054377978.1 → XP_054233953.1  unconventional myosin-IXa isoform X2

  37. XM_054377981.1 → XP_054233956.1  unconventional myosin-IXa isoform X3

  38. XM_054377974.1 → XP_054233949.1  unconventional myosin-IXa isoform X1

  39. XM_054378006.1 → XP_054233981.1  unconventional myosin-IXa isoform X12

  40. XM_054378017.1 → XP_054233992.1  unconventional myosin-IXa isoform X17

  41. XM_054377996.1 → XP_054233971.1  unconventional myosin-IXa isoform X8

  42. XM_054377990.1 → XP_054233965.1  unconventional myosin-IXa isoform X6

  43. XM_054377987.1 → XP_054233962.1  unconventional myosin-IXa isoform X5

  44. XM_054378001.1 → XP_054233976.1  unconventional myosin-IXa isoform X10

  45. XM_054377999.1 → XP_054233974.1  unconventional myosin-IXa isoform X9

  46. XM_054378012.1 → XP_054233987.1  unconventional myosin-IXa isoform X14

  47. XM_054377984.1 → XP_054233959.1  unconventional myosin-IXa isoform X4

  48. XM_054377980.1 → XP_054233955.1  unconventional myosin-IXa isoform X2

  49. XM_054377976.1 → XP_054233951.1  unconventional myosin-IXa isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RTY4.2 GenPept UniProtKB/Swiss-Prot:B2RTY4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous