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NTP Technical Report on the Toxicology and Carcinogenesis Studies of Glycidamide (CASRN 5694-00-8) in F344/N Nctr Rats and B6C3F1/Nctr Mice (Drinking Water Studies): Technical Report 588 [Internet].

National Toxicology Program.

Research Triangle Park (NC): National Toxicology Program; 2014 Nov.

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Select item 42172302.

Mirabegron Extended-Release Tablets (Myrbetriq): Treatment of Overactive Bladder (OAB) with Symptoms of Urgency, Urgency Incontinence and Urinary Frequency [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jul.

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Select item 42625963.

Darunavir/Cobicistat (Prezcobix) [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jul.

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Select item 42165844.

Macitentan (Opsumit): For Long-Term Treatment of Pulmonary Arterial Hypertension [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jul.

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Select item 42243765.

Prostaglandin Analogues for Ophthalmic Use: A Review of the Comparative Clinical Effectiveness and Cost-Effectiveness [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jul 30.

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Select item 46608066.

Clinical Review Report: Slexipag (Uptravi) [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Sep.

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Select item 48773367.

Clinical Review Report: Baricitinib (Olumiant): (Eli Lilly Canada Inc.): Indication: For use in combination with methotrexate (MTX) for the treatment of adult patients with moderate to severe rheumatoid arthritis who have responded inadequately to one or more disease-modifying antirheumatic drugs (DMARDs). Baricitinib may also be used as monotherapy in cases of intolerance to MTX [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2019 Sep.

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Select item 47616348.

Common Drug Review New Combination Product Submission: Darunavir/Cobicistat/Emtricitabine/Tenofovir alafenamide (Symtuza): (Janssen Canada Inc.): Indication: A complete regimen for the treatment of HIV type 1 infection in adults and adolescents (aged 12 years and older with body weight at least 40 kg) with no known mutations associated with resistance to the individual components of Symtuza [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Aug.

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Select item 42564989.

Third-Line Pharmacotherapy for Type 2 Diabetes — Update [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2013 Jul. (CADTH Optimal Use Report, No. 3.1B.)

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Select item 407442610.

Guidelines on Post-Exposure Prophylaxis for HIV and the Use of Co-Trimoxazole Prophylaxis for HIV-Related Infections Among Adults, Adolescents and Children: Recommendations for a Public Health Approach: December 2014 supplement to the 2013 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection.

Geneva: World Health Organization; 2014 Dec.

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Select item 227207611.

Self-Administered Drug Treatments for Acute Migraine Headache.

Gray RN, McCrory DC, Eberlein K, et al.

Rockville (MD): Agency for Health Care Policy and Research (US); 1999 Feb. (Technical Reviews, No. 2.4.)

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Select item 498100212.

NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Study of 3’-Azido-3’-deoxythymidine (AZT), Trimethoprim (TMP)/Sulfamethoxazole (SMX), and Folinic Acid Combinations Administered by Gavage to Swiss (CD-1®) Mice [Internet].

Rao GN, Cirvello JD, Rogers TR, et al.

Research Triangle Park (NC): National Institute of Environmental Health Sciences; 1998 Dec. (Toxicity Report, No. 2.)

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Select item 487755613.

Pharmacoeconomic Review Report: Baricitinib (Olumiant): (Eli Lilly Canada Inc.): Indication: For use in combination with methotrexate (MTX) for the treatment of adult patients with moderate to severe rheumatoid arthritis who have responded inadequately to one or more disease-modifying antirheumatic drugs (DMARDs). Baricitinib may also be used as monotherapy in cases of intolerance to MTX [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2019 Sep.

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Select item 466351614.

Clinical Review Report: Sofosbuvir / Velpatasvir / Voxilaprevir (Vosevi): (Gilead Sciences Canada, Inc.): Indication: Hepatitis C infection genotype 1 to 6 [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Feb.

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Select item 235805215.

Probe Reports from the NIH Molecular Libraries Program [Internet].

Bethesda (MD): National Center for Biotechnology Information (US); 2010-.

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Select item 339236616.

Holkira (Ombitasvir/Paritaprevir/ Ritonavir with Dasabuvir) and Harvoni (Ledipasvir/Sofosbuvir) for Chronic Hepatitis C: A Review of the Clinical Evidence [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jan 16.

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Select item 466487417.

Pharmacoeconomic Review Report: Sofosbuvir/Velpatasvir/Voxilaprevir (Vosevi): (Gilead Sciences Canada, Inc.): Indication: Hepatitis C infection genotype 1 to 6 [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Feb.

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Select item 313144618.

Assessment of the Role of Intermittent Preventive Treatment for Malaria in Infants: Letter Report.

Institute of Medicine (US) Committee on the Perspectives on the Role of Intermittent Preventive Treatment for Malaria in Infants.

Washington (DC): National Academies Press (US); 2008.

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Select item 462936419.

Linezolid for the Treatment of Infections: A Review of the Clinical and Cost-Effectiveness [Internet].

Kanga I, Poitras V, Ford C.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Oct 25.

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Select item 461291220.

Screening for Syphilis Infection in Pregnant Women: A Reaffirmation Evidence Update for the U.S. Preventive Services Task Force [Internet].

Lin JS, Eder M, Bean S.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2018 Sep. (Evidence Synthesis, No. 167.)

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FIGURE 4.14

(a) The general structure of novel carbohydrate-based polymers (the length, n, can be varied between 56 and 100) that are efficient intracellular nucleic acid delivery vehicles. The synthetic structures, polymerized via click chemistry, contain a disaccharide for lowering toxicity and heterocycles, amides, and amines that facilitate self-assembly via electrostatic interactions with DNA into (b) viral mimetic nanoparticles. SOURCE: S. Srinivasachari, Y. Liu, G. Zhang, L. Prevette, and T.M. Reineke, “Trehalose click polymers inhibit nanoparticle aggregation and promote pDNA delivery in serum,“ Journal of the American Chemical Society 128:8176 (2006). Copyright 2006 American Chemical Society.

Probes and Tools for Biomolecular Materials Research.

National Research Council (US) Committee on Biomolecular Materials and Processes. Inspired by Biology: From Molecules to Materials to Machines. Washington (DC): National Academies Press (US); 2008.
Figure 2

NAD binding pocket of human CtBP1. Side chain and peptide backbone of critical residues the NAD binding pocket of hCtBP1 are shown in stick representation (backbone oxygens are omitted for clarity) (Protein Data Bank entry 1MX3).13 NAD is shown as a space-filling model. Glu296, His315, and Arg266 are presumed catalytic residues conserved among D-2-hydroxyacid dehydrogenases. A conserved glycine-rich loop between Gly181 and Gly186 of hCtBP1 interacts with the pyrophosphate moiety of NAD. Substitution mutations within this region diminish or abolish NAD binding and enzymatic activity of related dehydrogenases. In addition to interactions with backbone amides of Arg184, Val185, and Trp318 and carbonyl groups of Cys237 and Thr264 (not shown), side chains of Arg184, Asp204, Asn240 and Asp290 additionally stabilize NAD binding,. An acetate incorporated from crystallization solutions hydrogen bonded to His315, Arg266 and Arg 97 is shown in the active site adjacent to the nicotinamide ring.

Structural Determinants of CtBP Function.

Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013.
Figure 2

Schematic representations of protein-DNA contacts for each of the five minor groove-binding architectural proteins. The numbering for the DNA bases and the protein residues is the same as in the original papers, and the DNA is viewed looking into the minor groove. Deoxyribose rings are represented as pentagons, phosphates as hollow circles, and purine (A,G) and pyrimidine (C,T) bases as long black rectangles and short black rectangles, respectively. Hydrophobic contacts are shown by solid arrows, hydrogen bonds and electrostatic contacts by dashed arrows, and contacts between protein backbone amides and DNA as dotted arrows. (For clarity, no distinction is made between hydrogen bonds and direct or indirect electrostatic interactions.) The identity of each nucleotide is shown in the center of its deoxyribose ring, and the protein residues are shown in italics. Intermolecular contacts are shown for (a) yeast TBP and the TATA element from the yeast CYC1(-52) promoter and Arabidopsis thaliana TBP and the TATA element of the adenovirus major late promoter; labels end with y or a, respectively (note that the bases of basepair 5 are represented as hollow rectangles because A or T is observed at this site); (b) the HMG box domain of SRY and the MIS gene consensus sequence; (c) the HMG box domain of LEF-1 and the TCRα gene consensus sequence; (d) IHF and the H′ site of phage 8 (the asterisk by T29–G30 indicates the site of the nick); (e) DBD2 of HMG I(Y) and a dodecamer comprising PRDII of the IFN β enhancer.

Minor Groove-Binding Architectural Proteins: Structure, Function, and DNA Recognition.

Annual Reviews Collection [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2002 Nov.