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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1957 1
1990 3
1991 5
1992 13
1993 27
1994 41
1995 53
1996 90
1997 95
1998 108
1999 124
2000 140
2001 182
2002 170
2003 143
2004 171
2005 160
2006 167
2007 167
2008 149
2009 127
2010 153
2011 144
2012 152
2013 131
2014 149
2015 150
2016 128
2017 128
2018 135
2019 127
2020 119
2021 153
2022 113
2023 115
2024 37

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3,722 results

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Page 1
A real-world data analysis of topotecan in the FDA Adverse Event Reporting System (FAERS) database.
Yang H, Wan Z, Chen M, Zhang X, Cui W, Zhao B. Yang H, et al. Expert Opin Drug Metab Toxicol. 2023 Apr;19(4):217-223. doi: 10.1080/17425255.2023.2219390. Epub 2023 May 30. Expert Opin Drug Metab Toxicol. 2023. PMID: 37243615
METHODS: To assess the disproportionality of topotecan-related AEs in real-world data, four algorithms (ROR, PRR, BCPNN, and EBGM) were employed as measures to detect signals of topotecan-associated AEs. ...Among these reports, 1,896 were identified as primary suspe …
METHODS: To assess the disproportionality of topotecan-related AEs in real-world data, four algorithms (ROR, PRR, BCPNN, and EBGM) we …
Clinical status and optimal use of topotecan.
Takimoto CH, Arbuck SG. Takimoto CH, et al. Oncology (Williston Park). 1997 Nov;11(11):1635-46; discussion 1649-51, 1655-7. Oncology (Williston Park). 1997. PMID: 9394364 Free article. Review.
Studies evaluating topotecan combinations as initial treatment in such diseases as ovarian and small-cell lung carcinoma are also underway. ...Whether or not such hopes are realized, these important studies will help define the role of topotecan in cancer chemothera …
Studies evaluating topotecan combinations as initial treatment in such diseases as ovarian and small-cell lung carcinoma are also und …
Topotecan in cervical cancer.
Ackermann S, Beckmann MW, Thiel F, Bogenrieder T. Ackermann S, et al. Int J Gynecol Cancer. 2007 Nov-Dec;17(6):1215-23. doi: 10.1111/j.1525-1438.2007.01003.x. Int J Gynecol Cancer. 2007. PMID: 17997795 Review.
We therefore conducted a systematic review on the studies using topotecan in cervical cancer. Seven phase I-III clinical trials using topotecan, both as a single agent and in combination with cisplatin or paclitaxel, in patients with recurrent or advanced carcinoma …
We therefore conducted a systematic review on the studies using topotecan in cervical cancer. Seven phase I-III clinical trials using …
Ocular pharmacology of topotecan and its activity in retinoblastoma.
Schaiquevich P, Carcaboso AM, Buitrago E, Taich P, Opezzo J, Bramuglia G, Chantada GL. Schaiquevich P, et al. Retina. 2014 Sep;34(9):1719-27. doi: 10.1097/IAE.0000000000000253. Retina. 2014. PMID: 25099219 Review.
Topotecan administered intraophthalmic artery shows higher passage to the vitreous compared with periocular administration in a swine model. CONCLUSION: Topotecan alone or in combination is active against retinoblastoma. ...
Topotecan administered intraophthalmic artery shows higher passage to the vitreous compared with periocular administration in a swine …
Delayed vaccine-induced CD8+ T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication.
van der Sluis TC, van Haften FJ, van Duikeren S, Pardieck IN, de Graaf JF, Vleeshouwers W, van der Maaden K, Melief CJM, van der Burg SH, Arens R. van der Sluis TC, et al. J Immunother Cancer. 2023 Nov 29;11(11):e007158. doi: 10.1136/jitc-2023-007158. J Immunother Cancer. 2023. PMID: 38030302 Free PMC article.
RESULTS: We show that E7 long peptide vaccination combined with cisplatin and topotecan, results in CD8(+) T cell-dependent durable rejection of established tumors and 94% long-term survival. Although topotecan initially repressed the expansion of vaccine-induced CD …
RESULTS: We show that E7 long peptide vaccination combined with cisplatin and topotecan, results in CD8(+) T cell-dependent durable r …
Topotecan in the management of cervical cancer.
Randall-Whitis LM, Monk BJ. Randall-Whitis LM, et al. Expert Opin Pharmacother. 2007 Feb;8(2):227-36. doi: 10.1517/14656566.8.2.227. Expert Opin Pharmacother. 2007. PMID: 17257092 Review.
Topotecan, a semisynthetic camptothecin, exerts its cytotoxic effect through inhibition of DNA topoisomerase I. Single-agent topotecan has demonstrated activity against persistent, metastatic and recurrent cancer of the uterine cervix. ...
Topotecan, a semisynthetic camptothecin, exerts its cytotoxic effect through inhibition of DNA topoisomerase I. Single-agent topot …
Topotecan Liposomes: A Visit from a Molecular to a Therapeutic Platform.
Saraf S, Jain A, Hurkat P, Jain SK. Saraf S, et al. Crit Rev Ther Drug Carrier Syst. 2016;33(5):401-432. doi: 10.1615/CritRevTherDrugCarrierSyst.2016015926. Crit Rev Ther Drug Carrier Syst. 2016. PMID: 27910741 Review.
Topotecan (TPT), a potent anticancer camptothecin analog, is well described for the treatment of ovarian cancer, but has also anticancer activity against small-cell and non-small-cell lung cancer, breast cancer, and acute leukemia. ...
Topotecan (TPT), a potent anticancer camptothecin analog, is well described for the treatment of ovarian cancer, but has also antican …
Clinical experience with topotecan in relapsed ovarian cancer.
Herzog TJ. Herzog TJ. Gynecol Oncol. 2003 Sep;90(3 Pt 2):S3-7. doi: 10.1016/s0090-8258(03)00467-0. Gynecol Oncol. 2003. PMID: 13129489 Review.
Encouraging preliminary data suggest that alternative dosing schedules may improve the therapeutic index of topotecan and that topotecan may also be active as first-line therapy in combination with taxanes and/or platinum agents. Optimization of the use of topote …
Encouraging preliminary data suggest that alternative dosing schedules may improve the therapeutic index of topotecan and that top …
Topotecan for relapsed small cell lung cancer: a systematic review and economic evaluation.
Hartwell D, Jones J, Loveman E, Harris P, Clegg A, Bird A. Hartwell D, et al. Cancer Treat Rev. 2011 May;37(3):242-9. doi: 10.1016/j.ctrv.2010.07.005. Epub 2010 Aug 14. Cancer Treat Rev. 2011. PMID: 20709456 Review.
BACKGROUND: Topotecan is a relatively new drug for use as a second-line treatment in patients with relapsed small cell lung cancer (SCLC). ...The clinical evidence indicates a statistically significant benefit of oral topotecan plus BSC compared to BSC alone for ove …
BACKGROUND: Topotecan is a relatively new drug for use as a second-line treatment in patients with relapsed small cell lung cancer (S …
3,722 results