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1980 1
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1992 3
1993 2
1994 7
1995 2
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2000 7
2001 2
2002 2
2003 5
2004 9
2005 7
2006 9
2007 3
2008 10
2009 7
2010 10
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Page 1
Tizanidine.
Ghanavatian S, Derian A. Ghanavatian S, et al. 2023 Aug 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Aug 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30137790 Free Books & Documents.
Tizanidine is an FDA-approved drug for managing spasticity. It is a centrally acting alpha-2 receptor agonist. ...This activity outlines the indications, mechanism of action, methods of administration, significant adverse effects, toxicity, and monitoring, of …
Tizanidine is an FDA-approved drug for managing spasticity. It is a centrally acting alpha-2 receptor agonist. ...This activity outli …
New directions in the treatment of opioid withdrawal.
Srivastava AB, Mariani JJ, Levin FR. Srivastava AB, et al. Lancet. 2020 Jun 20;395(10241):1938-1948. doi: 10.1016/S0140-6736(20)30852-7. Lancet. 2020. PMID: 32563380 Free PMC article. Review.
Newer agents likewise exploit these pharmacological mechanisms, including tramadol (mu-opioid receptor agonism) and tizanidine (alpha2 agonism). Areas for future research include managing withdrawal in the context of stabilising patients with opioid use disorder to extende …
Newer agents likewise exploit these pharmacological mechanisms, including tramadol (mu-opioid receptor agonism) and tizanidine (alpha …
Choosing a skeletal muscle relaxant.
See S, Ginzburg R. See S, et al. Am Fam Physician. 2008 Aug 1;78(3):365-70. Am Fam Physician. 2008. PMID: 18711953 Free article. Review.
Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited. Adverse effects, particularly dizziness and drowsiness, are consistently reported with all skeletal muscle relaxants. The potential adverse effects should be co …
Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited. Adverse effects, particularly dizz …
Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review.
Chou R, Peterson K, Helfand M. Chou R, et al. J Pain Symptom Manage. 2004 Aug;28(2):140-75. doi: 10.1016/j.jpainsymman.2004.05.002. J Pain Symptom Manage. 2004. PMID: 15276195 Free article. Review.
There is fair evidence that baclofen and tizanidine are roughly equivalent for efficacy in patients with spasticity, but insufficient evidence to determine the efficacy of dantrolene compared to baclofen or tizanidine. There is fair evidence that although the overal …
There is fair evidence that baclofen and tizanidine are roughly equivalent for efficacy in patients with spasticity, but insufficient …
Pharmacotherapy for Spine-Related Pain in Older Adults.
Fu JL, Perloff MD. Fu JL, et al. Drugs Aging. 2022 Jul;39(7):523-550. doi: 10.1007/s40266-022-00946-x. Epub 2022 Jun 27. Drugs Aging. 2022. PMID: 35754070 Review.
Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are avoided in older adults due to risk for sedation and falls. Others (tizanidine, baclofen, dantrolene) may be helpful for neck and back pain, with the most …
Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are avoided in older adult …
Interventions for managing skeletal muscle spasticity following traumatic brain injury.
Synnot A, Chau M, Pitt V, O'Connor D, Gruen RL, Wasiak J, Clavisi O, Pattuwage L, Phillips K. Synnot A, et al. Cochrane Database Syst Rev. 2017 Nov 22;11(11):CD008929. doi: 10.1002/14651858.CD008929.pub2. Cochrane Database Syst Rev. 2017. PMID: 29165784 Free PMC article. Review.
Only studies where at least 50% of participants had a TBI (or for whom separate data for participants with TBI were available) were included. The primary outcomes were spasticity and adverse effects. Secondary outcome measures were classified according to the World …
Only studies where at least 50% of participants had a TBI (or for whom separate data for participants with TBI were available) were included …
Comparative effectiveness and safety of analgesic medicines for adults with acute non-specific low back pain: systematic review and network meta-analysis.
Wewege MA, Bagg MK, Jones MD, Ferraro MC, Cashin AG, Rizzo RR, Leake HB, Hagstrom AD, Sharma S, McLachlan AJ, Maher CG, Day R, Wand BM, O'Connell NE, Nikolakopolou A, Schabrun S, Gustin SM, McAuley JH. Wewege MA, et al. BMJ. 2023 Mar 22;380:e072962. doi: 10.1136/bmj-2022-072962. BMJ. 2023. PMID: 36948512 Free PMC article.
DATA EXTRACTION AND SYNTHESIS: Primary outcomes were low back pain intensity (0-100 scale) at end of treatment and safety (number of participants who reported any adverse event during treatment). Secondary outcomes were low back specific function, serious adverse ev …
DATA EXTRACTION AND SYNTHESIS: Primary outcomes were low back pain intensity (0-100 scale) at end of treatment and safety (number of partici …
Spastic Paraplegia 3A.
Hedera P. Hedera P. 2010 Sep 21 [updated 2020 Jun 18]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2010 Sep 21 [updated 2020 Jun 18]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20862796 Free Books & Documents. Review.
Medical treatment of spasticity may begin with oral baclofen or tizanidine, followed by chemodenervation with botulinum A or B toxins if oral antispasticity medications are not tolerated. Intrathecal baclofen pump may be considered for those who improve on oral baclofen bu …
Medical treatment of spasticity may begin with oral baclofen or tizanidine, followed by chemodenervation with botulinum A or B toxins …
Safety of baclofen versus tizanidine for older adults with musculoskeletal pain.
Su Zhang VR, Niu F, Lee EA, DiStasio C, Broder BI, Steinberg SG, Hui RL. Su Zhang VR, et al. J Am Geriatr Soc. 2023 Aug;71(8):2579-2584. doi: 10.1111/jgs.18349. Epub 2023 Mar 29. J Am Geriatr Soc. 2023. PMID: 36989193
BACKGROUND: Baclofen and tizanidine are both muscle relaxants that carry the risk for neuropsychiatric events in older adults but there is a lack of data directly comparing their safety. ...RESULTS: The final study cohort included 12,101 and 6,027 older adults in the baclo …
BACKGROUND: Baclofen and tizanidine are both muscle relaxants that carry the risk for neuropsychiatric events in older adults but the …
Phenytoin-tizanidine interaction.
Ueno K, Miyai K, Mitsuzane K. Ueno K, et al. DICP. 1991 Nov;25(11):1273. doi: 10.1177/106002809102501124. DICP. 1991. PMID: 1722371 No abstract available.
179 results