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2006 1
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2015 28
2016 44
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2020 27
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Page 1
Pharmacokinetics and Pharmacodynamics of Tedizolid.
Iqbal K, Milioudi A, Wicha SG. Iqbal K, et al. Clin Pharmacokinet. 2022 Apr;61(4):489-503. doi: 10.1007/s40262-021-01099-7. Epub 2022 Feb 7. Clin Pharmacokinet. 2022. PMID: 35128625 Free PMC article. Review.
The aim of the review was to summarize and critically review the key pharmacokinetic and pharmacodynamic aspects of tedizolid. Tedizolid displays linear pharmacokinetics with good tissue penetration. ...The presence of granulocytes augmented its antibacterial effect …
The aim of the review was to summarize and critically review the key pharmacokinetic and pharmacodynamic aspects of tedizolid. Ted …
Overview of Changes to the Clinical and Laboratory Standards Institute Performance Standards for Antimicrobial Susceptibility Testing, M100, 31st Edition.
Humphries R, Bobenchik AM, Hindler JA, Schuetz AN. Humphries R, et al. J Clin Microbiol. 2021 Nov 18;59(12):e0021321. doi: 10.1128/JCM.00213-21. Epub 2021 Sep 22. J Clin Microbiol. 2021. PMID: 34550809 Free PMC article. Review.
Updates to test methods include a method for disk diffusion using positive blood culture broth and use of linezolid to predict tedizolid susceptibility. There is clarification on which drugs to suppress on bacteria isolated from the cerebrospinal fluid and clarification on …
Updates to test methods include a method for disk diffusion using positive blood culture broth and use of linezolid to predict tedizolid …
An evaluation of tedizolid for the treatment of MRSA infections.
Hall RG 2nd, Smith WJ, Putnam WC, Pass SE. Hall RG 2nd, et al. Expert Opin Pharmacother. 2018 Sep;19(13):1489-1494. doi: 10.1080/14656566.2018.1519021. Epub 2018 Sep 10. Expert Opin Pharmacother. 2018. PMID: 30200779 Review.
Areas covered: This review summarizes the randomized controlled trials that evaluated the clinical efficacy of tedizolid in ABSSSIs, which is currently the only United States Food and Drug Administration-labeled indication for tedizolid. ...Potential indications for …
Areas covered: This review summarizes the randomized controlled trials that evaluated the clinical efficacy of tedizolid in ABSSSIs, …
Tedizolid: a new oxazolidinone antimicrobial.
Kisgen JJ, Mansour H, Unger NR, Childs LM. Kisgen JJ, et al. Am J Health Syst Pharm. 2014 Apr 15;71(8):621-33. doi: 10.2146/ajhp130482. Am J Health Syst Pharm. 2014. PMID: 24688035 Review.
Tedizolid has a favorable pharmacokinetic profile that allows for once-daily dosing and easy i.v....In clinical trials to date, overall rates of treatment-related adverse effects with linezolid and tedizolid were comparable (40.8% versus 43.3%), with nausea being th …
Tedizolid has a favorable pharmacokinetic profile that allows for once-daily dosing and easy i.v....In clinical trials to date, overa …
Tedizolid: The First Once-Daily Oxazolidinone Class Antibiotic.
Burdette SD, Trotman R. Burdette SD, et al. Clin Infect Dis. 2015 Oct 15;61(8):1315-21. doi: 10.1093/cid/civ501. Epub 2015 Jun 23. Clin Infect Dis. 2015. PMID: 26105167 Review.
It is a prodrug that is rapidly converted to the active compound tedizolid. Tedizolid has activity against a wide range of gram-positive pathogens, including methicillin-resistant Staphylococcus aureus. ...These 2 ABSSSI studies have positioned tedizolid amon …
It is a prodrug that is rapidly converted to the active compound tedizolid. Tedizolid has activity against a wide range of gra …
Differences in Pharmacokinetic/Pharmacodynamic Parameters of Tedizolid Against VRE and MRSA.
Liu X, Tashiro S, Igarashi Y, Takemura W, Kojima N, Morita T, Hayashi M, Enoki Y, Taguchi K, Matsumoto K. Liu X, et al. Pharm Res. 2023 Jan;40(1):187-196. doi: 10.1007/s11095-022-03425-5. Epub 2022 Nov 3. Pharm Res. 2023. PMID: 36329373
Therefore, we aimed to determine the PK/PD indices of tedizolid action on VRE and the mechanisms underlying the PK/PD indices differences of tedizolid against VRE and methicillin-resistant Staphylococcus aureus (MRSA). ...Correlations were closest betw …
Therefore, we aimed to determine the PK/PD indices of tedizolid action on VRE and the mechanisms underlying the PK/PD i …
Tedizolid: a novel oxazolidinone with potent activity against multidrug-resistant gram-positive pathogens.
Zhanel GG, Love R, Adam H, Golden A, Zelenitsky S, Schweizer F, Gorityala B, Lagacé-Wiens PR, Rubinstein E, Walkty A, Gin AS, Gilmour M, Hoban DJ, Lynch JP 3rd, Karlowsky JA. Zhanel GG, et al. Drugs. 2015 Feb;75(3):253-70. doi: 10.1007/s40265-015-0352-7. Drugs. 2015. PMID: 25673021 Review.
Tedizolid does not require dosage adjustment in patients with any degree of renal dysfunction or hepatic dysfunction. ...As with linezolid, tedizolid is a weak, reversible MAO inhibitor; however, a murine head twitch model validated to assess serotonergic activity r …
Tedizolid does not require dosage adjustment in patients with any degree of renal dysfunction or hepatic dysfunction. ...As with line …
The role of tedizolid in skin and soft tissue infections.
Bouza E, Muñoz P, Burillo A. Bouza E, et al. Curr Opin Infect Dis. 2018 Apr;31(2):131-140. doi: 10.1097/QCO.0000000000000439. Curr Opin Infect Dis. 2018. PMID: 29346119 Review.
PURPOSE OF REVIEW: Tedizolid is a second-generation oxazolidinone with activity against Gram-positive bacteria, including MRSA isolates resistant to linezolid. ...The comparison of adverse events is favorable to tedizolid under the circumstances of the clinical tria …
PURPOSE OF REVIEW: Tedizolid is a second-generation oxazolidinone with activity against Gram-positive bacteria, including MRSA isolat …
Tedizolid for the management of human infections: in vitro characteristics.
Locke JB, Zurenko GE, Shaw KJ, Bartizal K. Locke JB, et al. Clin Infect Dis. 2014 Jan;58 Suppl 1:S35-42. doi: 10.1093/cid/cit616. Clin Infect Dis. 2014. PMID: 24343830 Review.
Strains harboring such mutations are also selected for much less frequently with tedizolid than with linezolid. In addition, tedizolid has a significant potency advantage over linezolid-resistant strains carrying the horizontally transferable cfr gene. ...The greate …
Strains harboring such mutations are also selected for much less frequently with tedizolid than with linezolid. In addition, tediz …
Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response.
Sharon D, Cathelin S, Mirali S, Di Trani JM, Yanofsky DJ, Keon KA, Rubinstein JL, Schimmer AD, Ketela T, Chan SM. Sharon D, et al. Sci Transl Med. 2019 Oct 30;11(516):eaax2863. doi: 10.1126/scitranslmed.aax2863. Sci Transl Med. 2019. PMID: 31666400
Pharmacologic inhibition of mitochondrial protein synthesis with antibiotics that target the ribosome, including tedizolid and doxycycline, effectively overcame venetoclax resistance. ...The addition of tedizolid to azacitidine and venetoclax further enhanced the ki …
Pharmacologic inhibition of mitochondrial protein synthesis with antibiotics that target the ribosome, including tedizolid and doxycy …
320 results