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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1968 1
1969 1
1970 2
1975 1
1977 1
1980 1
1981 3
1982 2
1985 1
1990 1
1992 1
1993 1
1997 1
1998 3
1999 5
2001 1
2002 2
2006 1
2007 1
2008 1
2014 1
2022 1
2024 0

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34 results

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Page 1
Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Clinical Trial.
Nurko S, Saps M, Kossowsky J, Zion SR, Di Lorenzo C, Vaz K, Hawthorne K, Wu R, Ciciora S, Rosen JM, Kaptchuk TJ, Kelley JM. Nurko S, et al. JAMA Pediatr. 2022 Apr 1;176(4):349-356. doi: 10.1001/jamapediatrics.2021.5750. JAMA Pediatr. 2022. PMID: 35099543 Free PMC article. Clinical Trial.
A standardized method for explaining the OLP was used, and the interaction with clinicians had the same duration and style for both time periods. Hyoscyamine was allowed as a rescue medication. MAIN OUTCOMES AND MEASURES: The primary outcome was the mean daily pain score d …
A standardized method for explaining the OLP was used, and the interaction with clinicians had the same duration and style for both time per …
A controlled trial of glycopyrronium and l-hyoscyamine in the long-term treatment of duodenal ulcer.
Kaye MD, Rhodes J, Beck P, Sweetnam PM, Davies GT, Evans KT. Kaye MD, et al. Gut. 1970 Jul;11(7):559-66. doi: 10.1136/gut.11.7.559. Gut. 1970. PMID: 4916211 Free PMC article. Clinical Trial.
Patients were divided randomly into three groups. They received either glycopyrronium, or 1-hyoscyamine in a sustained-release form, or inert tablets for one year. Progress was judged on the basis of frequency and severity of symptoms, monthly assessments by patients, anta …
Patients were divided randomly into three groups. They received either glycopyrronium, or 1-hyoscyamine in a sustained-release form, …
Antispasmodic drugs to reduce discomfort and colonic spasm during barium enemas: comparison of oral hyoscyamine, i.v. glucagon, and no drug.
Bova JG, Jurdi RA, Bennett WF. Bova JG, et al. AJR Am J Roentgenol. 1993 Nov;161(5):965-8. doi: 10.2214/ajr.161.5.8273637. AJR Am J Roentgenol. 1993. PMID: 8273637 Clinical Trial.

Fewer patients in the group who received no medication (10%) had no or mild pain compared with those given glucagon (15%, p < .05), 0.125 mg of hyoscyamine (14%, p < .05), or 0.25 mg of hyoscyamine (12%, p = .15). ...In addition, hyoscyamine is consider

…

Fewer patients in the group who received no medication (10%) had no or mild pain compared with those given glucagon (15%, p < .05), 0.125

…
Comparison of no medication, placebo, and hyoscyamine for reducing pain during a barium enema.
Bova JG, Bhattacharjee N, Jurdi R, Bennett WF. Bova JG, et al. AJR Am J Roentgenol. 1999 May;172(5):1285-7. doi: 10.2214/ajr.172.5.10227503. AJR Am J Roentgenol. 1999. PMID: 10227503 Clinical Trial.
SUBJECTS AND METHODS: Patients were randomized into three groups: no medication, placebo, and sublingual 1-hyoscyamine sulfate. The placebo or hyoscyamine tablet was placed under the tongue 15-30 min before the examination. ...CONCLUSION: Although safe, hyoscyami …
SUBJECTS AND METHODS: Patients were randomized into three groups: no medication, placebo, and sublingual 1-hyoscyamine sulfate. The p …
Intramuscular atropine in healthy volunteers: a pharmacokinetic and pharmacodynamic study.
Kentala E, Kaila T, Iisalo E, Kanto J. Kentala E, et al. Int J Clin Pharmacol Ther Toxicol. 1990 Sep;28(9):399-404. Int J Clin Pharmacol Ther Toxicol. 1990. PMID: 2228327 Clinical Trial.
The absorption rate and the elimination rate of dl-hyoscyamine and l-hyoscyamine were comparable (tmax = 8.40 vs 8.67 min, t1/2el = 2.95 vs 2.43 h, dose 0.02 mg/kg) but the mean maximum plasma concentration of dl-hyoscyamine was 2.9 times and the mean AUC val …
The absorption rate and the elimination rate of dl-hyoscyamine and l-hyoscyamine were comparable (tmax = 8.40 vs 8.67 min, t1/ …
Sublingual hyoscyamine for patient comfort during screening sigmoidoscopy: a randomized, double-blind, placebo-controlled clinical trial.
Dumot JA, Verzola E, Nicol S, Easley KA, Vargo JJ, van Stolk RU. Dumot JA, et al. Gastrointest Endosc. 1998 Sep;48(3):283-6. doi: 10.1016/s0016-5107(98)70192-0. Gastrointest Endosc. 1998. PMID: 9744605 Clinical Trial.
The possible benefit of a well-tolerated, low-cost antispasmodic medication, sublingual hyoscyamine, used before flexible sigmoidoscopy was assessed in a randomized, double-blinded, placebo-controlled trial. METHODS: One hundred fifty patients were enrolled and randomized …
The possible benefit of a well-tolerated, low-cost antispasmodic medication, sublingual hyoscyamine, used before flexible sigmoidosco …
Sublingual hyoscyamine spray as premedication for colonoscopy: a randomized double-blinded placebo-controlled trial.
Chaptini LA, Janec EM, Seltzer G, Peikin S, Elfant AB. Chaptini LA, et al. Am J Surg. 2008 Jul;196(1):51-5. doi: 10.1016/j.amjsurg.2007.06.030. Epub 2008 Apr 24. Am J Surg. 2008. PMID: 18436182 Clinical Trial.
The aim of this study was to determine the effect of sublingual hyoscyamine spray (IB-Stat, Inkine Pharmaceutical) on the performance of colonoscopy. ...CONCLUSIONS: Procedural difficulty and colonic motility scores were significantly lower in subjects who received subling …
The aim of this study was to determine the effect of sublingual hyoscyamine spray (IB-Stat, Inkine Pharmaceutical) on the performance …
Sublingual L-hyoscyamine for duodenal antimotility during ERCP: a prospective randomized double-blinded study.
Lynch CR, Khandekar S, Lynch SM, Disario JA. Lynch CR, et al. Gastrointest Endosc. 2007 Oct;66(4):748-52. doi: 10.1016/j.gie.2007.02.052. Gastrointest Endosc. 2007. PMID: 17905018 Clinical Trial.
OBJECTIVE: Demonstrate whether pre-ERCP sublingual L-hyoscyamine reduces the amount of glucagon required to complete ERCP. ...CONCLUSIONS: Preprocedure administration of sublingual L-hyoscyamine did not reduce the amount of glucagon required to complete ERCP....
OBJECTIVE: Demonstrate whether pre-ERCP sublingual L-hyoscyamine reduces the amount of glucagon required to complete ERCP. ...CONCLUS …
The effect of pirenzepine and L-hyoscyamine on gastric emptying and salivary secretion in healthy volunteers.
Jaup BH, Dotevall G. Jaup BH, et al. Scand J Gastroenterol. 1981;16(6):769-73. doi: 10.3109/00365528109181002. Scand J Gastroenterol. 1981. PMID: 6119766 Clinical Trial.
The difference between L-hyoscyamine and pirenzepine was statistically significant for the time in which the volume fell to 75% and 50% (p less than 0.01). The salivation was significantly more inhibited by L-hyoscyamine than by pirenzepine. Pirenzepine in doses inh …
The difference between L-hyoscyamine and pirenzepine was statistically significant for the time in which the volume fell to 75% and 5 …
Systemic bioavailability of ocularly applied 1% atropine eyedrops.
Kaila T, Korte JM, Saari KM. Kaila T, et al. Acta Ophthalmol Scand. 1999 Apr;77(2):193-6. doi: 10.1034/j.1600-0420.1999.770215.x. Acta Ophthalmol Scand. 1999. PMID: 10321537 Free article. Clinical Trial.
The plasma concentrations of the biologically active atropine enantiomer, 1-hyoscyamine, were determined using a muscarinic cholinoceptor binding assay. ...Large interindividual differences characterized the absorption and elimination phases of 1-hyoscyamine kinetic …
The plasma concentrations of the biologically active atropine enantiomer, 1-hyoscyamine, were determined using a muscarinic cholinoce …
34 results