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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1970 2
1971 2
1972 1
1973 2
1974 4
1983 1
1985 1
1986 1
1988 1
1989 1
1991 1
1996 2
1997 3
1998 3
1999 5
2000 3
2001 1
2002 2
2003 6
2004 6
2005 3
2006 4
2007 4
2008 6
2009 7
2010 8
2011 10
2012 6
2013 13
2014 9
2015 11
2016 8
2017 10
2018 9
2019 9
2020 19
2021 13
2022 12
2023 4
2024 1

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188 results

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Page 1
Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma.
Arrowitz C, Schoelermann AM, Mann T, Jiang LI, Weber T, Kolbe L. Arrowitz C, et al. J Invest Dermatol. 2019 Aug;139(8):1691-1698.e6. doi: 10.1016/j.jid.2019.02.013. Epub 2019 Feb 27. J Invest Dermatol. 2019. PMID: 30825454 Free article. Clinical Trial.
To investigate new treatment options, we performed an exploratory double-blinded, randomized split-face study to assess the efficacy of the tyrosinase inhibitor Thiamidol compared to hydroquinone in women with mild to moderate melasma. After 12 weeks, modified Melasma Area …
To investigate new treatment options, we performed an exploratory double-blinded, randomized split-face study to assess the efficacy of the …
Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase.
Mann T, Gerwat W, Batzer J, Eggers K, Scherner C, Wenck H, Stäb F, Hearing VJ, Röhm KH, Kolbe L. Mann T, et al. J Invest Dermatol. 2018 Jul;138(7):1601-1608. doi: 10.1016/j.jid.2018.01.019. Epub 2018 Feb 7. J Invest Dermatol. 2018. PMID: 29427586 Free article. Clinical Trial.
Therefore, we used recombinant human tyrosinase to screen a library of 50,000 compounds and compared the active screening hits with well-known whitening ingredients. Hydroquinone and its derivative arbutin only weakly inhibited human tyrosinase with a half-maximal inhibito …
Therefore, we used recombinant human tyrosinase to screen a library of 50,000 compounds and compared the active screening hits with well-kno …
Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide.
Shariff R, Du Y, Dutta M, Kumar S 5th, Thimmaiah S, Doraiswamy C, Kumari A, Kale V, Nair N, Zhang S, Joshi M, Santhanam U, Qiang Q, Damodaran A. Shariff R, et al. Int J Cosmet Sci. 2022 Feb;44(1):103-117. doi: 10.1111/ics.12759. Epub 2022 Feb 1. Int J Cosmet Sci. 2022. PMID: 34958693 Free PMC article. Clinical Trial.
This study demonstrates that a product designed to affect multiple pathways of melanogenesis, inflammation, and ageing may provide an additional treatment option, beyond hydroquinone and retinoids, for hyperpigmentation and ageing....
This study demonstrates that a product designed to affect multiple pathways of melanogenesis, inflammation, and ageing may provide an additi …
Melasma.
Kauh YC, Zachian TF. Kauh YC, et al. Adv Exp Med Biol. 1999;455:491-9. doi: 10.1007/978-1-4615-4857-7_72. Adv Exp Med Biol. 1999. PMID: 10599387 Clinical Trial.
We have conducted a clinical trial utilizing all trans-retinoic acid (tretinoin, Retin-A) cream 0.1% q pm and hydroquinone lotion 3% (Melanex) applied every morning in Korean women with melasma. ...We reconfirmed that a synergistic mechanism between tretinoin and hydroq …
We have conducted a clinical trial utilizing all trans-retinoic acid (tretinoin, Retin-A) cream 0.1% q pm and hydroquinone lotion 3% …
Comparison of 2% deoxyarbutin and 4% hydroquinone as a depigmenting agent in healthy individuals: A double-blind randomized controlled clinical trial.
Anwar AI, Asmarani Y, Madjid A, Patellongi I, Adriani A, As'ad S, Kurniadi I. Anwar AI, et al. J Cosmet Dermatol. 2021 Dec;20(12):3953-3959. doi: 10.1111/jocd.14050. Epub 2021 Mar 23. J Cosmet Dermatol. 2021. PMID: 33683782 Clinical Trial.
BACKGROUND: Hydroquinone, which is considered the gold standard skin depigmenting agent, has been associated with multiple side effects. Lately, deoxyarbutin has been suggested to be an alternative of hydroquinone with better safety profile. OBJECTIVE: To compare th …
BACKGROUND: Hydroquinone, which is considered the gold standard skin depigmenting agent, has been associated with multiple side effec …
Melasma: treatment evaluation.
Salem A, Gamil H, Ramadan A, Harras M, Amer A. Salem A, et al. J Cosmet Laser Ther. 2009 Sep;11(3):146-50. doi: 10.1080/14764170902842549. J Cosmet Laser Ther. 2009. PMID: 19340686 Clinical Trial.
METHODS: A total of 45 patients with moderate-to-severe melasma were subjected to topical application of hydroquinone 4% cream, chemical peeling with 30% trichloroacetic acid (TCA) and/or frequency-doubled Q-switched Nd:YAG laser therapy for an average of 6 months. ...The …
METHODS: A total of 45 patients with moderate-to-severe melasma were subjected to topical application of hydroquinone 4% cream, chemi …
Efficacy and safety of a novel picosecond laser using combination of 1 064 and 595 nm on patients with melasma: A prospective, randomized, multicenter, split-face, 2% hydroquinone cream-controlled clinical trial.
Choi YJ, Nam JH, Kim JY, Min JH, Park KY, Ko EJ, Kim BJ, Kim WS. Choi YJ, et al. Lasers Surg Med. 2017 Dec;49(10):899-907. doi: 10.1002/lsm.22735. Epub 2017 Sep 14. Lasers Surg Med. 2017. PMID: 28906574 Clinical Trial.
We evaluated the efficacy and safety of a picosecond laser with dual-wavelengths (1 064 and 595 nm) and topical 2% hydroquinone (HQ) combination therapy on patients with melasma, and compared results with those obtained with 2% HQ alone. ...
We evaluated the efficacy and safety of a picosecond laser with dual-wavelengths (1 064 and 595 nm) and topical 2% hydroquinone (HQ) …
Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance.
Wu H, Gabriel TA, Burney WA, Chambers CJ, Pan A, Sivamani RK. Wu H, et al. Arch Dermatol Res. 2023 Jul;315(5):1207-1214. doi: 10.1007/s00403-022-02514-0. Epub 2022 Dec 11. Arch Dermatol Res. 2023. PMID: 36502500 Clinical Trial.
Currently, the first line topical medication in the United States is hydroquinone. Hydroquinone use is associated with potential safety concerns including cytotoxicity to melanocytes, systemic absorption, metabolism in distant organs, and production of potentially c …
Currently, the first line topical medication in the United States is hydroquinone. Hydroquinone use is associated with potenti …
An effective hydroquinone alternative for topical skin lightening.
Draelos ZD, Deliencourt-Godefroy G, Lopes L. Draelos ZD, et al. J Cosmet Dermatol. 2020 Dec;19(12):3258-3261. doi: 10.1111/jocd.13771. Epub 2020 Nov 16. J Cosmet Dermatol. 2020. PMID: 33098161 Clinical Trial.
BACKGROUND: Many skin lightening preparations containing hydroquinone, kojic acid, arbutin, and deoxyarbutin are toxic to melanocytes. ...All subjects underwent facial photography at each visit. RESULTS: TFC-1067 and 2% hydroquinone produced statistically significan …
BACKGROUND: Many skin lightening preparations containing hydroquinone, kojic acid, arbutin, and deoxyarbutin are toxic to melanocytes …
Clinical efficacy and safety of a multimodality skin brightener composition compared with 4% hydroquinone.
Makino ET, Mehta RC, Garruto J, Gotz V, Sigler ML, Herndon JH. Makino ET, et al. J Drugs Dermatol. 2013 Mar;12(3):s21-6. J Drugs Dermatol. 2013. PMID: 23545929 Clinical Trial.
While these conditions are of an aesthetic nature, there is great interest in newer, safer, and more effective treatment modalities. Topical hydroquinone (HQ) has been the gold standard of skin lighteners for many years. ...
While these conditions are of an aesthetic nature, there is great interest in newer, safer, and more effective treatment modalities. Topical …
188 results