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American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation.
Chang L, Chey WD, Imdad A, Almario CV, Bharucha AE, Diem S, Greer KB, Hanson B, Harris LA, Ko C, Murad MH, Patel A, Shah ED, Lembo AJ, Sultan S. Chang L, et al. Gastroenterology. 2023 Jun;164(7):1086-1106. doi: 10.1053/j.gastro.2023.03.214. Gastroenterology. 2023. PMID: 37211380 Free PMC article.
Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: a systematic review.
Ruston T, Hunter K, Cummings G, Lazarescu A. Ruston T, et al. Can Oncol Nurs J. 2013 Autumn;23(4):236-46. doi: 10.5737/1181912x234236240. Can Oncol Nurs J. 2013. PMID: 24428006 Review. English, French.
Opioid-induced constipation (OIC) is a side effect of opioid therapy that can affect quality of life, adherence to treatment, and morbidity and possibly mortality. OBJECTIVES: To investigate whether docusate sodium, sennosides, and lactulose have equal efficacy and …
Opioid-induced constipation (OIC) is a side effect of opioid therapy that can affect quality of life, adherence to treatment, and morbidity …
The Role of Docusate for Constipation in Older People.
Nguyen T. Nguyen T. Sr Care Pharm. 2021 Oct 1;36(10):501-507. doi: 10.4140/TCP.n.2021.501. Sr Care Pharm. 2021. PMID: 34593092
Data Synthesis: Docusate when compared with placebo or psyllium or sennosides in these trials did not show any benefits for constipation. Psyllium and sennosides showed to be more effective compared with docusate. No differences found between docusa …
Data Synthesis: Docusate when compared with placebo or psyllium or sennosides in these trials did not show any benefits for co …
A comparison of sennosides-based bowel protocols with and without docusate in hospitalized patients with cancer.
Hawley PH, Byeon JJ. Hawley PH, et al. J Palliat Med. 2008 May;11(4):575-81. doi: 10.1089/jpm.2007.0178. J Palliat Med. 2008. PMID: 18454610
The docusate-containing protocol had an initial docusate-only step for patients not taking opioids, and four to six 100-mg capsules of docusate sodium in addition to the sennosides for the rest of the protocol. METHODS: Thirty patients received the …
The docusate-containing protocol had an initial docusate-only step for patients not taking opioids, and four to six 100-mg cap …
Update in hospital palliative care.
Anderson WG, Flint LA, Horton JR, Johnson K, Mourad M, Sharpe BA. Anderson WG, et al. J Hosp Med. 2013 Dec;8(12):715-20. doi: 10.1002/jhm.2110. Epub 2013 Nov 8. J Hosp Med. 2013. PMID: 24214838 Free PMC article. Review.
RESULTS: Key findings include: indwelling pleural catheters and talc pleurodesis provide similar relief of dyspnea in patients with malignant pleural effusions; oxygen many not be needed to prevent dyspnea in many dying patients; docusate may not be needed in addition to …
RESULTS: Key findings include: indwelling pleural catheters and talc pleurodesis provide similar relief of dyspnea in patients with malignan …
Palatability of Crushed Over-the-Counter Medications.
Lovell AG, Protus BM, Dickman JR, Saphire ML. Lovell AG, et al. J Pain Symptom Manage. 2021 Apr;61(4):755-762. doi: 10.1016/j.jpainsymman.2020.09.020. Epub 2020 Sep 22. J Pain Symptom Manage. 2021. PMID: 32976943 Free article.
Eight OTC medications were crushed and mixed in applesauce: naproxen, fexofenadine, phenazopyridine, multivitamin, loperamide, famotidine, sennosides, and sennosides-docusate. Participants were blinded to medication samples and control (plain applesauce). ... …
Eight OTC medications were crushed and mixed in applesauce: naproxen, fexofenadine, phenazopyridine, multivitamin, loperamide, famotidine, …
Medication Use Evaluation of Docusate Sodium in Constipation Prophylaxis and Opioid Induced Constipation at the WPB VA HCS Community Living Center.
Faulkner W, DiScala S, Vartan C, Dakroub B, Silverman M, Bharadwaj M. Faulkner W, et al. Am J Hosp Palliat Care. 2023 Nov 24:10499091231218390. doi: 10.1177/10499091231218390. Online ahead of print. Am J Hosp Palliat Care. 2023. PMID: 37999649
INTRODUCTION: Docusate sodium's efficacy is widely debated. Several studies on opioid induced constipation (OIC) concluded that docusate sodium vs either placebo or in combination with sennosides provided no benefit. ...Patients were included if they had oral …
INTRODUCTION: Docusate sodium's efficacy is widely debated. Several studies on opioid induced constipation (OIC) concluded that do …
The efficacy of docusate sodium and senna glycoside for the treatment of constipation after rotator cuff repair: A randomized controlled study.
Weekes DG, Campbell RE, Giunta NJ, Pepe MD, Tucker BS, Londahl-Ramsey VE, Tjoumakaris FP. Weekes DG, et al. J Am Assoc Nurse Pract. 2021 Feb 18;34(1):62-69. doi: 10.1097/JXX.0000000000000575. J Am Assoc Nurse Pract. 2021. PMID: 33625162 Clinical Trial.
METHODS: Patients (n = 107) were randomized to receive docusate sodium, senna glycoside, or nothing (control) in addition to a standardized postoperative protocol. ...There was no difference in the prevalence of constipation in the docusate, senna, and control group …
METHODS: Patients (n = 107) were randomized to receive docusate sodium, senna glycoside, or nothing (control) in addition to a standa …
Randomized, double-blind, placebo-controlled trial of oral docusate in the management of constipation in hospice patients.
Tarumi Y, Wilson MP, Szafran O, Spooner GR. Tarumi Y, et al. J Pain Symptom Manage. 2013 Jan;45(1):2-13. doi: 10.1016/j.jpainsymman.2012.02.008. Epub 2012 Aug 11. J Pain Symptom Manage. 2013. PMID: 22889861 Free article. Clinical Trial.
There is little experimental evidence to support this practice, and no randomized trials have been conducted in the hospice setting. OBJECTIVES: To assess the efficacy of docusate in hospice patients. METHODS: This was a 10-day, prospective, randomized, double-blind, place …
There is little experimental evidence to support this practice, and no randomized trials have been conducted in the hospice setting. OBJECTI …
Treatments for Constipation: A Review of Systematic Reviews [Internet].
[No authors listed] [No authors listed] Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Nov 17. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Nov 17. PMID: 25535635 Free Books & Documents. Review.
Stool softeners (i.e. docusate sodium or calcium) are thought to facilitate the mixing of aqueous and fatty substances and thereby soften the stool. ...A recent Rapid Review concluded there was a paucity of good quality of evidence to support the use of stool softeners for …
Stool softeners (i.e. docusate sodium or calcium) are thought to facilitate the mixing of aqueous and fatty substances and thereby so …
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