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Chronobiology and Pharmacologic Modulation of the Renin-Angiotensin-Aldosterone System in Dogs: What Have We Learned?
Mochel JP, Danhof M. Mochel JP, et al. Rev Physiol Biochem Pharmacol. 2015;169:43-69. doi: 10.1007/112_2015_27. Rev Physiol Biochem Pharmacol. 2015. PMID: 26428686 Review.
A thorough characterization of the chronobiology of the renin cascade has the potential to streamline the therapeutic management of RAAS-related diseases and to help determining the optimal time of drug administration that maximizes efficacy of ACE inhibitors, while minimizing th …
A thorough characterization of the chronobiology of the renin cascade has the potential to streamline the therapeutic management of RAAS-rel …
Antihypertensive and organ-protective effects of benazepril.
Barrios V, Escobar C. Barrios V, et al. Expert Rev Cardiovasc Ther. 2010 Dec;8(12):1653-71. doi: 10.1586/erc.10.159. Expert Rev Cardiovasc Ther. 2010. PMID: 21108548 Review.
Benazepril is a nonsulfhydryl ACE inhibitor with favorable pharmacodynamic and pharmacokinetic properties, well-established antihypertensive effects and a good tolerability profile. Recent clinical studies have demonstrated that patients treated with benazepril alone or in …
Benazepril is a nonsulfhydryl ACE inhibitor with favorable pharmacodynamic and pharmacokinetic properties, well-established antihypertensive …
Simultaneous determination of lercanidipine, benazepril and benazeprilat in plasma by LC-MS/MS and its application to a toxicokinetics study.
Chen K, Zhang J, Liu S, Zhang D, Teng Y, Wei C, Wang B, Liu X, Yuan G, Zhang R, Zhao W, Guo R. Chen K, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 15;899:1-7. doi: 10.1016/j.jchromb.2012.04.014. Epub 2012 May 8. J Chromatogr B Analyt Technol Biomed Life Sci. 2012. PMID: 22622066
We aim to develop a rapid, simple, sensitive and specific LC-MS/MS method for the simultaneous quantification of lercanidipine, benazepril and benazeprilat in plasma. It is performed on the Agilent 6410 LC-MS/MS under the multiple-reaction monitoring (MRM) mode with electr …
We aim to develop a rapid, simple, sensitive and specific LC-MS/MS method for the simultaneous quantification of lercanidipine, benazepril a …
Benazepril. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and congestive heart failure.
Balfour JA, Goa KL. Balfour JA, et al. Drugs. 1991 Sep;42(3):511-39. doi: 10.2165/00003495-199142030-00008. Drugs. 1991. PMID: 1720384 Review.
Benazepril is a nonsulfhydryl ACE inhibitor prodrug, which is converted in vivo to its active form, benazeprilat. Data from clinical studies have indicated that benazepril 5 to 80 mg (usually 10 to 20 mg), administered as a single daily dose, effectively decreases blood pr …
Benazepril is a nonsulfhydryl ACE inhibitor prodrug, which is converted in vivo to its active form, benazeprilat. Data from clinical …
Bioavailability study of fixed-dose tablet versus capsule formulation of amlodipine plus benazepril: A randomized, single-dose, two-sequence, two-period, open-label, crossover study in healthy volunteers.
Chien KL, Chao CL, Su TC. Chien KL, et al. Curr Ther Res Clin Exp. 2005 Mar;66(2):69-79. doi: 10.1016/j.curtheres.2005.04.005. Curr Ther Res Clin Exp. 2005. PMID: 24672114 Free PMC article.
The mean (SD) relative bioavailabilities, as represented by AUC0-, of amlodipine and benazeprilat for tablets versus capsules were 1.060 (0.170) versus 0.949 (0.197), respectively. The mean plasma concentration-time profiles of amlodipine and benazeprilat were graph …
The mean (SD) relative bioavailabilities, as represented by AUC0-, of amlodipine and benazeprilat for tablets versus capsules were 1. …
The effects of age on the pharmacokinetics and pharmacodynamics of single oral doses of benazepril and enalapril.
Macdonald NJ, Sioufi A, Howie CA, Wade JR, Elliott HL. Macdonald NJ, et al. Br J Clin Pharmacol. 1993 Sep;36(3):205-9. doi: 10.1111/j.1365-2125.1993.tb04218.x. Br J Clin Pharmacol. 1993. PMID: 9114905 Free PMC article. Clinical Trial.
The hypotensive effect was similar after both drugs but the absolute reductions were greater in the elderly who had higher initial levels of blood pressure. 3. The AUCs for both benazeprilat and enalaprilat were higher in the elderly but by a significantly greater amount f …
The hypotensive effect was similar after both drugs but the absolute reductions were greater in the elderly who had higher initial levels of …
Pharmacokinetic interaction study between benazepril and amlodipine in healthy subjects.
Sun JX, Cipriano A, Chan K, John VA. Sun JX, et al. Eur J Clin Pharmacol. 1994;47(3):285-9. doi: 10.1007/BF02570510. Eur J Clin Pharmacol. 1994. PMID: 7867683 Clinical Trial.
Serial blood samples were collected following each administration for the determination of benazepril and its active metabolite benazeprilat and amlodipine. The mean values of AUC (0-4 h), Cmax and Tmax for benazepril given as combination versus given alone were 161 vs 140 …
Serial blood samples were collected following each administration for the determination of benazepril and its active metabolite benazepri …
Site-differential gastrointestinal absorption of benazepril hydrochloride in healthy volunteers.
Chan KK, Buch A, Glazer RD, John VA, Barr WH. Chan KK, et al. Pharm Res. 1994 Mar;11(3):432-7. doi: 10.1023/a:1018925407109. Pharm Res. 1994. PMID: 8008712 Clinical Trial.
Serial plasma and urine samples were collected for up to 4 days after dosing. BZPH and its active metabolite benazeprilat (BZPL) were determined using a gas chromatography/mass spectrometry method. ...
Serial plasma and urine samples were collected for up to 4 days after dosing. BZPH and its active metabolite benazeprilat (BZPL) were …