Oligomycins

A closely related group of toxic substances elaborated by various strains of Streptomyces. They are 26-membered macrolides with lactone moieties and double bonds and inhibit various ATPases, causing uncoupling of phosphorylation from mitochondrial respiration. Used as tools in cytochemistry. Some specific oligomycins are RUTAMYCIN, peliomycin, and botrycidin (formerly venturicidin X).

Year introduced: 1982

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Tree Number(s): D02.540.505.620

MeSH Unique ID: D009840

Entry Terms:

• Oligomycin

Pharmacologic Action:

• Anti-Bacterial Agents
• Enzyme Inhibitors
• Uncoupling Agents

All MeSH Categories
Chemicals and Drugs Category
Organic Chemicals
Lactones
Macrolides
Oligomycins
Rutamycin