Lymphocyte Function-Associated Antigen-1
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
Year introduced: 1991
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Tree Number(s): D09.400.430.890.200.074.937, D09.400.430.890.200.625.550, D12.776.395.550.200.074.937, D12.776.395.550.200.625.550, D12.776.543.550.200.093.937, D12.776.543.550.200.625.550, D12.776.543.750.705.408.600.400, D12.776.543.750.705.877.550, D23.050.301.350.074.400, D23.050.301.350.625.550
MeSH Unique ID: D016169
Entry Terms:
- Antigen-1, Lymphocyte Function-Associated
- Lymphocyte Function Associated Antigen 1
- Leukocyte Function Associated Antigen-1
- LFA-1
- Integrin alphaLbeta2
- alphaLbeta2, Integrin
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