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    kin-3 Casein kinase II subunit alpha [ Caenorhabditis elegans ]

    Gene ID: 172978, updated on 23-Nov-2023

    Summary

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    Gene symbol
    kin-3
    Gene description
    Casein kinase II subunit alpha
    Primary source
    WormBase:WBGene00002191
    Locus tag
    CELE_B0205.7
    See related
    AllianceGenome:WB:WBGene00002191
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation; response to hermaphrodite contact; and vulval location. Located in several cellular components, including dendrite; neuronal cell body; and non-motile cilium. Part of protein kinase CK2 complex. Orthologous to several human genes including CSNK2A1 (casein kinase 2 alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (10734022..10736615)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene YtxH domain-containing protein Neighboring gene 26S proteasome non-ATPase regulatory subunit 4 Neighboring gene Large ribosomal subunit protein bL9m Neighboring gene ncRNA Neighboring gene cysteine desulfurase Neighboring gene Transposase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of wild-type and mutated forms of the catalytic (alpha) subunit of Caenorhabditis elegans casein kinase II in Escherichia coli. Hu E, et al. J Biol Chem, 1990 Nov 25. PMID 2243106
    2. Effects of calcium on recombinant bovine chromogranin A. Angeletti RH, et al. Protein Sci, 1992 Dec. PMID 1304892, Free PMC Article
    3. Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1. Alessi AF, et al. Proc Natl Acad Sci U S A, 2015 Dec 29. PMID 26669440, Free PMC Article
    4. Protein kinase CK2 is required for Wntless internalization and Wnt secretion. de Groot RE, et al. Cell Signal, 2014 Dec. PMID 25178265
    5. Casein kinase II and calcineurin modulate TRPP function and ciliary localization. Hu J, et al. Mol Biol Cell, 2006 May. PMID 16481400, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hermaphrodite contact IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval location IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein kinase CK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein kinase CK2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Casein kinase II subunit alpha
    NP_492811.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10734022..10736615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060410.5 → NP_492811.1  Casein kinase II subunit alpha [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492811.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18334
      Conserved Domains (2) summary
      cd14132
      Location:19 → 323
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
      pfam00069
      Location:38 → 323
      Pkinase; Protein kinase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18334.1

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