Am J Public Health. 1998 Sep;88(9):1377-80.

Evaluating cluster alarms: a space-time scan statistic and brain cancer in Los Alamos, New Mexico.

Kulldorff M, Athas WF, Feurer EJ, Miller BA, Key CR.

Source

Division of Cancer Prevention, National Cancer Institute, Bethesda, Md 20892-7368, USA.

Abstract

OBJECTIVES:

This article presents a space-time scan statistic, useful for evaluating space-time cluster alarms, and illustrates the method on a recent brain cancer cluster alarms in Los Alamos, NM.

METHODS:

The space-time scan statistic accounts for the preselection bias and multiple testing inherent in a cluster alarm. Confounders and time trends can be adjusted for.

RESULTS:

The observed excess of brain cancer in Los Alamos was not statistically significant.

CONCLUSIONS:

The space-time scan statistic is useful as a screening tool for evaluating which cluster alarms merit further investigation and which clusters are probably chance occurrences.

PMID:: 9736881; [PubMed - indexed for MEDLINE]
PMCID: PMC1509064

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Evaluating cluster alarms: a space-time scan statistic and brain cancer in Los Alamos, New Mexico.

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Abstract

OBJECTIVES:

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RESULTS:

CONCLUSIONS:

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