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    Cell. 1998 Feb 20;92(4):559-71.

    Sec3p is a spatial landmark for polarized secretion in budding yeast.

    Finger FP, Hughes TE, Novick P.

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    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8002, USA.

    Abstract

    Exocytosis in yeast occurs at plasma membrane subdomains whose locations vary with the cell cycle, but the primary protein determinants of these sites are unknown. A functional fusion of Sec3 protein with green fluorescent protein (Sec3-GFP) localizes to the site of polarized exocytosis for each cell-cycle stage, where it colocalizes with Sec4p and Sec8p. Sec3-GFP localization is independent of secretory pathway function, of the actin and septin cytoskeletons, and of the polarity establishment proteins. We propose that Sec3p is a spatial landmark defining sites of exocytosis. Polarized secretion would result from the coupling of actin-dependent vesicle targeting with Sec3p-dependent establishment of the vesicle fusion site.

    PMID:
    9491896
    [PubMed - indexed for MEDLINE]

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