J Clin Pharmacol. 1976 Jul;16(7):321-8.

Variability of 24-hour urinary creatinine excretion by normal subjects.

Greenblatt DJ, Ransil BJ, Harmatz JS, Smith TW, Duhme DW, Koch-Weser J.

Abstract

Creatinine excretion was studied in eight healthy males who collected 54 to 97 24-hour urine specimens. Significant differences among subjects in mean creatinine excretion were only partly explained by differences in body weight and surface area. Considerable daily within-subject variation in creatinine excretion during normal activity was found. Standard deviations were from 10.5 to 14.4 per cent of the mean, and ranges varied from 50 to 79 per cent of the mean. Day-to-day variation appeared to be time dependent rather than entirely random, and could not be explained by unreliability of the assay technique or by incomplete collections. Creatinine excretion values were normally distributed in seven of eight subjects. Individual variation from day to day limits the value of urinary creatinine excretion as an index of the completeness of 24-hour urine collections.

PMID:: 947964; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Creatinine

LinkOut - more resources

Full Text Sources

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

The use of creatinine output as a check on the completeness of 24-hour urine collections. [Hum Nutr Clin Nutr. 1985]
The use of creatinine output as a check on the completeness of 24-hour urine collections.
Bingham SA, Cummings JH. Hum Nutr Clin Nutr. 1985 Sep; 39(5):343-53.
Evidence for systematic temporal variation in 24-hour urinary creatinine excretion. [J Clin Pharmacol. 1977]
Evidence for systematic temporal variation in 24-hour urinary creatinine excretion.
Ransil BJ, Greenblatt DJ, Koch-Weser J. J Clin Pharmacol. 1977 Feb-Mar; 17(2-3):108-19.
Reproducibility of renal function measurements in adult men with diabetic nephropathy: research and clinical implications. [Am J Nephrol. 2007]
Reproducibility of renal function measurements in adult men with diabetic nephropathy: research and clinical implications.
Agarwal R. Am J Nephrol. 2007; 27(1):92-100. Epub 2007 Feb 7.
Can two-, four- or eight-hour urine collections after voluntary voiding be used instead of twenty-four-hour collections for the estimation of creatinine clearance in healthy subjects? [Pharm World Sci. 1998]
Can two-, four- or eight-hour urine collections after voluntary voiding be used instead of twenty-four-hour collections for the estimation of creatinine clearance in healthy subjects?
Markantonis SL, Agathokleous-Kioupaki E. Pharm World Sci. 1998 Dec; 20(6):258-63.
Review Creatinine excretion as a measure of protein nutrition in adults of varying age. [JPEN J Parenter Enteral Nutr. ...]
Review Creatinine excretion as a measure of protein nutrition in adults of varying age.
Walser M. JPEN J Parenter Enteral Nutr. 1987 Sep-Oct; 11(5 Suppl):73S-78S.

See reviews... See all...

Cited by 7 PubMed Central articles

Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate. [Kidney Int. 2010]
Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate.
Waikar SS, Sabbisetti VS, Bonventre JV. Kidney Int. 2010 Sep; 78(5):486-94. Epub 2010 Jun 16.
Concentrations versus amounts of biomarkers in urine: a comparison of approaches to assess pyrethroid exposure. [Environ Health. 2008]
Concentrations versus amounts of biomarkers in urine: a comparison of approaches to assess pyrethroid exposure.
Fortin MC, Carrier G, Bouchard M. Environ Health. 2008 Nov 4; 7:55. Epub 2008 Nov 4.
A semiparametric modeling framework for potential biomarker discovery and the development of metabonomic profiles. [BMC Bioinformatics. 2008]
A semiparametric modeling framework for potential biomarker discovery and the development of metabonomic profiles.
Ghosh S, Grant DF, Dey DK, Hill DW. BMC Bioinformatics. 2008 Jan 23; 9:38. Epub 2008 Jan 23.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Variability of 24-hour urinary creatinine excretion by normal subjects.
Variability of 24-hour urinary creatinine excretion by normal subjects.
J Clin Pharmacol. 1976 Jul ;16(7):321-8.

PubMed
TGF-beta1-binding proteins on human bone marrow stromal cells.
TGF-beta1-binding proteins on human bone marrow stromal cells.
Leuk Lymphoma. 1997 Nov ;27(5-6):509-15.

PubMed
The fate of 2,4-dichlorophenoxyacetic acid (2,4-D) following oral administration...
The fate of 2,4-dichlorophenoxyacetic acid (2,4-D) following oral administration to man.
Toxicology. 1977 Aug ;8(1):3-11.

PubMed
Biomonitoring exposure to environmental tobacco smoke (ETS): a critical reapprai...
Biomonitoring exposure to environmental tobacco smoke (ETS): a critical reappraisal.
Hum Exp Toxicol. 1997 Aug ;16(8):449-59.

PubMed
Upper genital tract changes associated with exposure in utero to diethylstilbest...
Upper genital tract changes associated with exposure in utero to diethylstilbestrol.
Obstet Gynecol Surv. 1977 Sep ;32(7):611-3.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: