J Nat Prod. 1998 Jan;61(1):135-8.

Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine.

Maruyama Y, Kuribara H, Morita M, Yuzurihara M, Weintraub ST.

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Department of Neuropsychopharmacology, Gunma University School of Medicine, Japan. yuji@news.sb.gunma-u.ac.jp

Abstract

The principal active anxiolytic components in Saiboku-to, an Oriental herbal medicine, have been isolated and identified as magnolol (5,5'-di-2-propenyl-1,1'-biphenyl-2,2'-diol) and honokiol (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol). Evaluation by means of an elevated plus-maze test showed that honokiol was at least 5000 times more potent than Saiboku-to when mice were treated orally for 7 days.

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Cited by 5 PubMed Central articles

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Chemical compound information

honokiol

MW: 266.33 g/mol

MF: C₁₈H₁₈O₂

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