Lancet. 1979 Dec 22-29;2(8156-8157):1313-5.

Aspirin and secondary mortality after myocardial infarction.

Abstract

A randomised controlled double-blind trial of aspirin in the prevention of death was conducted in 1682 patients (including 248 women) who had had a confirmed myocardial infarct (MI). 25% of the patients were admitted to the trial within 3 days of the infarction and 50% within 7 days. Aspirin, 300 mg three times daily, was given for 1 yr. Total mortality was 12.3% in patients given aspirin and 14.8% in those given placebo, a reduction by aspirin of 17%, which was not statistically significant at p less than 0.05. The reduction in specific ischaemic-heart-disease (IHD) mortality was 22% and in total mortality plus IHD morbidity (readmission to hospital for MI in survivors) was 28%.

PMID:: 92668; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

The German-Austrian aspirin trial: a comparison of acetylsalicylic acid, placebo and phenprocoumon in secondary prevention of myocardial infarction. On behalf of the German-Austrian Study Group. [Circulation. 1980]
The German-Austrian aspirin trial: a comparison of acetylsalicylic acid, placebo and phenprocoumon in secondary prevention of myocardial infarction. On behalf of the German-Austrian Study Group.
Breddin K, Loew D, Lechner K, Oberla K, Walter E. Circulation. 1980 Dec; 62(6 Pt 2):V63-72.
Aspirin and secondary mortality after myocardial infarction. [Circulation. 1980]
Aspirin and secondary mortality after myocardial infarction.
Elwood PC, Sweetnam PM. Circulation. 1980 Dec; 62(6 Pt 2):V53-8.
Persantine-Aspirin Reinfarction Study. Part II. Secondary coronary prevention with persantine and aspirin. [J Am Coll Cardiol. 1986]
Persantine-Aspirin Reinfarction Study. Part II. Secondary coronary prevention with persantine and aspirin.
Klimt CR, Knatterud GL, Stamler J, Meier P. J Am Coll Cardiol. 1986 Feb; 7(2):251-69.
Review Antiplatelet agents in the prevention of cardiovascular morbidity and mortality in older patients with vascular disease. [Drugs Aging. 1999]
Review Antiplatelet agents in the prevention of cardiovascular morbidity and mortality in older patients with vascular disease.
Aronow WS. Drugs Aging. 1999 Aug; 15(2):91-101.
Review Prevention of recurrent myocardial infarction and sudden death with aspirin therapy. [Drug Intell Clin Pharm. 1987]
Review Prevention of recurrent myocardial infarction and sudden death with aspirin therapy.
Rumore MM, Goldstein GS. Drug Intell Clin Pharm. 1987 Dec; 21(12):961-9.

See reviews... See all...

Cited by 25 PubMed Central articles

Aspirin for the older person: report of a meeting at the Royal Society of Medicine, London, 3rd November 2011. [Ecancermedicalscience. 2012]
Aspirin for the older person: report of a meeting at the Royal Society of Medicine, London, 3rd November 2011.
Armitage J, Cuzick J, Elwood P, Longley M, Perkins A, Spencer K, Turner H, Porch S, Lyness S, Kennedy J, et al. Ecancermedicalscience. 2012; 6:245. Epub 2012 Feb 28.
Aspirin use, dose, and clinical outcomes in postmenopausal women with stable cardiovascular disease: the Women's Health Initiative Observational Study. [Circ Cardiovasc Qual Outcomes....]
Aspirin use, dose, and clinical outcomes in postmenopausal women with stable cardiovascular disease: the Women's Health Initiative Observational Study.
Berger JS, Brown DL, Burke GL, Oberman A, Kostis JB, Langer RD, Wong ND, Wassertheil-Smoller S. Circ Cardiovasc Qual Outcomes. 2009 Mar; 2(2):78-87. Epub 2009 Mar 5.
Review The influence of gender on the effects of aspirin in preventing myocardial infarction. [BMC Med. 2007]
Review The influence of gender on the effects of aspirin in preventing myocardial infarction.
Yerman T, Gan WQ, Sin DD. BMC Med. 2007 Oct 18; 5:29. Epub 2007 Oct 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Aspirin and secondary mortality after myocardial infarction.
Aspirin and secondary mortality after myocardial infarction.
Lancet. 1979 Dec 22-29 ;2(8156-8157):1313-5.

PubMed
Cocaine and amphetamine preferentially stimulate glutamate release in the limbic...
Cocaine and amphetamine preferentially stimulate glutamate release in the limbic system: studies on the involvement of dopamine.
Synapse. 1997 Oct ;27(2):95-105.

PubMed
Studies on the uptake and binding of propranolol by rat tissues.
Studies on the uptake and binding of propranolol by rat tissues.
J Pharmacol Exp Ther. 1977 Dec ;203(3):621-9.

PubMed
Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase sub...
Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells.
J Clin Invest. 1997 Aug 15 ;100(4):942-8.

PubMed
Nickel coin dermatitis.
Nickel coin dermatitis.
Br Med J. 1977 Oct 15 ;2(6093):998.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Aspirin and secondary mortality after myocardial infarction.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 25 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information