Psychiatr Genet. 1997 Spring;7(1):45-7.

Functional promoter polymorphism of the human serotonin transporter: lack of association with panic disorder.

Deckert J, Catalano M, Heils A, Di Bella D, Friess F, Politi E, Franke P, Nöthen MM, Maier W, Bellodi L, Lesch KP.

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Department of Psychiatry, Julius-Maximilians-University, Wurzburg, Germany.

Abstract

To probe the hypothesis of a role for a functionally relevant 44 bp insertion/deletion of the serotonin transporter promoter in the aetiopathogenesis of panic disorder, we determined the allele frequency of the variant in two samples (combined n = 158) of panic disorder patients (DSMIII-R) and compared it with its allele frequency in two ethnically matched control samples (combined n = 169). The fact that no difference could be observed (x 2 analysis) argues against a major role for this serotonin transporter promoter polymorphism in the aetiopathogenesis of panic disorder.

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Functional promoter polymorphism of the human serotonin transporter: lack of association with panic disorder.

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