Int J Biochem Cell Biol. 1997 May;29(5):721-5.

The alpha v beta 3 integrin "vitronectin receptor".

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Department of Medicine, Jules Thorn Institute, Middlesex Hospital, London, UK.

Abstract

The alpha v beta 3 "vitronectin receptor" is a member of the integrin superfamily of adhesion molecules. As such, this 160/85 kDa heterodimeric protein exhibits many of the typical structural and functional features of integrins. It mediates cell adhesion to extracellular matrix by recognizing the conserved arg-gly-asp (RGD) sequence of several plasma and matrix proteins. Recently, it has also been shown that alpha v beta 3 is involved in signal transduction and cell to cell interactions. alpha v beta 3 is highly expressed in bone resorbing cells, osteoclasts, and upregulated in response to vascular damage, during angiogenesis and in certain types of malignancy. Antagonists of alpha v beta 3 are being developed for use in a variety of diseases associated with altered receptor function or level.

PMID:: 9251239; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Receptors, Vitronectin

Grant Support

Wellcome Trust/United Kingdom

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Cited by 33 PubMed Central articles

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