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    Vaccine. 1997 Jun;15(8):834-8.

    Protection against tuberculosis by a plasmid DNA vaccine.

    Lowrie DB, Silva CL, Colston MJ, Ragno S, Tascon RE.

    Source

    NIMR, London, UK.

    Abstract

    Past attempts to use fractions of mycobacteria as an alternative to BCG have given disappointing results. The availability of cloned genes and suitable vectors has now opened a new avenue in which individual mycobacterial protein antigens are synthesised within transfected mammalian cells. In an ex vivo transfection approach with a retroviral vector we found that even a single antigen (hsp65) could evoke strong protection when expressed as a transgene and that expression of protection was largely a function of antigen specific cytotoxic T cells. We now find that intramuscular injection of plasmid DNA expressing the antigen from either a viral or a murine promoter can also give protection equivalent to Bacillus Calmette-Guérin (BCG). Plasmids expressing some other mycobacterial antigens, hsp70, 36 kDa and 6 kDa, are also effective, suggesting that this approach may lead to a new vaccine.

    PMID:
    9234527
    [PubMed - indexed for MEDLINE]

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