Cytogenet Cell Genet. 1997;76(3-4):229-32.

Assignment of the chicken MAX gene to chromosome 5p by fluorescence in situ hybridization.

Nanda I, Peters MA, Taparowsky EJ, Sperling K, Schmid M.

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Department of Human Genetics, University of Würzburg, Biozentrum, Germany.

Abstract

It has been shown that the protein encoded by the MAX gene plays an important role in the physiological activity of Myc oncoproteins. In this study, we determined the chromosome location of the chicken MAX gene via fluorescence in situ hybridization. Hybridization of two biotinylated cloned fragments of 5.7 kb and 12.0 kb derived from the chicken MAX locus localized the gene to chromosome 5p. It is the third gene marker to be assigned to this telocentric macrochromosome. Since the MAX sequence is highly conserved both at the nucleotide and at the amino acid level in a wide range of vertebrate species, our data may provide evidence for the existence of a segmental homology between human and chicken chromosomes.

PMID:: 9186531; [PubMed - indexed for MEDLINE]

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Mapping of MAX to human chromosome 14 and mouse chromosome 12 by in situ hybridization. [Oncogene. 1992]
Mapping of MAX to human chromosome 14 and mouse chromosome 12 by in situ hybridization.
Gilladoga AD, Edelhoff S, Blackwood EM, Eisenman RN, Disteche CM. Oncogene. 1992 Jun; 7(6):1249-51.
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Assignment of the chicken MAX gene to chromosome 5p by fluorescence in situ hybridization.

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