J Leukoc Biol. 1997 Apr;61(4):375-80.

Apoptosis in resolution of inflammation.

Source

Department of Medicine, University Hospital, Nottingham, United Kingdom.

Abstract

The last few years have seen the accumulation of compelling evidence that apoptosis (programmed cell death) plays a major role in promoting resolution of the acute inflammatory response. Neutrophils are constitutively programmed to undergo apoptosis, which limits their pro-inflammatory potential and leads to rapid, specific, and non-phlogistic recognition by macrophages and semi-professional phagocytes. Similar mechanisms have been implicated in clearance of eosinophils, lymphocytes, and monocytes and apoptosis also plays a role in remodeling the inflamed site by deletion of myofibroblasts. A growing understanding of the mechanisms regulating leukocyte apoptosis and of the molecules mediating safe phagocytic clearance of dying cells may yield new insights into the pathogenesis and therapy of inflammatory diseases.

PMID:: 9103222; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

Wellcome Trust/United Kingdom

LinkOut - more resources

Full Text Sources

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Review Molecular regulation of neutrophil apoptosis and potential targets for therapeutic strategy against the inflammatory process. [Curr Drug Targets Inflamm Alle...]
Review Molecular regulation of neutrophil apoptosis and potential targets for therapeutic strategy against the inflammatory process.
Hofman P. Curr Drug Targets Inflamm Allergy. 2004 Mar; 3(1):1-9.
Review Granulocyte apoptosis and its role in the resolution and control of lung inflammation. [Am J Respir Crit Care Med. 1999]
Review Granulocyte apoptosis and its role in the resolution and control of lung inflammation.
Haslett C. Am J Respir Crit Care Med. 1999 Nov; 160(5 Pt 2):S5-11.
Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes. [Clin Sci (Lond). 1992]
Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes.
Haslett C. Clin Sci (Lond). 1992 Dec; 83(6):639-48.
Review Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation. [J Endocrinol. 2003]
Review Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation.
Heasman SJ, Giles KM, Ward C, Rossi AG, Haslett C, Dransfield I. J Endocrinol. 2003 Jul; 178(1):29-36.
Review Granulocyte apoptosis and the control of inflammation. [Philos Trans R Soc Lond B Biol...]
Review Granulocyte apoptosis and the control of inflammation.
Haslett C, Savill JS, Whyte MK, Stern M, Dransfield I, Meagher LC. Philos Trans R Soc Lond B Biol Sci. 1994 Aug 30; 345(1313):327-33.

See reviews... See all...

Cited by 67 PubMed Central articles

Smoking and idiopathic pulmonary fibrosis. [Pulm Med. 2012]
Smoking and idiopathic pulmonary fibrosis.
Oh CK, Murray LA, Molfino NA. Pulm Med. 2012; 2012:808260. Epub 2012 Feb 19.
Poractant alfa (Curosurf®) increases phagocytosis of apoptotic neutrophils by alveolar macrophages in vivo. [Respir Res. 2012]
Poractant alfa (Curosurf®) increases phagocytosis of apoptotic neutrophils by alveolar macrophages in vivo.
Willems CH, Urlichs F, Seidenspinner S, Kunzmann S, Speer CP, Kramer BW. Respir Res. 2012 Mar 9; 13:17. Epub 2012 Mar 9.
Decreased neutrophil apoptosis in quiescent ANCA-associated systemic vasculitis. [PLoS One. 2012]
Decreased neutrophil apoptosis in quiescent ANCA-associated systemic vasculitis.
Abdgawad M, Pettersson Å, Gunnarsson L, Bengtsson AA, Geborek P, Nilsson L, Segelmark M, Hellmark T. PLoS One. 2012; 7(3):e32439. Epub 2012 Mar 5.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Apoptosis in resolution of inflammation.
Apoptosis in resolution of inflammation.
J Leukoc Biol. 1997 Apr ;61(4):375-80.

PubMed
Cardiac output and pulmonary wedge pressure. Use for evaluation of fluid replace...
Cardiac output and pulmonary wedge pressure. Use for evaluation of fluid replacement in trauma patients.
Arch Surg. 1977 Oct ;112(10):1161-8.

PubMed
Tissue-factor antigen and activity in human coronary atherosclerotic plaques.
Tissue-factor antigen and activity in human coronary atherosclerotic plaques.
Lancet. 1997 Mar 15 ;349(9054):769-71.

PubMed
Multifactorial index of cardiac risk in noncardiac surgical procedures.
Multifactorial index of cardiac risk in noncardiac surgical procedures.
N Engl J Med. 1977 Oct 20 ;297(16):845-50.

PubMed
Dantrolene sodium reduces the enhanced leakage of creatine kinase caused by etha...
Dantrolene sodium reduces the enhanced leakage of creatine kinase caused by ethanol, cocaine, and electrical stimulation in isolated fast and slow muscles of rat.
Alcohol Clin Exp Res. 1997 Feb ;21(1):63-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: