Neuroendocrinology. 1977;23(4):248-56.

Iontophoretically applied corticosteroids do not affect the firing of hippocampal neurons.

Abstract

In view of the possible role of the hippocampus in the neuroendocrine regulation of ACTH secretion, experiments were conducted in rats and cats in which cortisol (C) and corticosterone (CS) were applied by iontophoresis and pressure microinjection while recording from single identified pyramidal cells in the dorsal hippocampus, using multi-barrelled microelectrodes. None of the more than 500 cells tested responded with a significant change in firing rate. The possible relation of these findings to neuroendocrine regulation of ACTH secretion is discussed.

PMID:: 909627; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

LinkOut - more resources

Molecular Biology Databases

HYDROCORTISONE - HSDB

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Rapid effects of corticosterone on cardiovascular neurons in the rostral ventrolateral medulla of rats. [Brain Res. 1999]
Rapid effects of corticosterone on cardiovascular neurons in the rostral ventrolateral medulla of rats.
Rong W, Wang W, Yuan W, Chen Y. Brain Res. 1999 Jan 2; 815(1):51-9.
Modifications in single cell activity in the rat midbrain during the iontophoretic application of cortisol. [Exp Neurol. 1983]
Modifications in single cell activity in the rat midbrain during the iontophoretic application of cortisol.
Papir-Kricheli D, Feldman S. Exp Neurol. 1983 Feb; 79(2):576-81.
[Steroid-sensitive neurons of the rabbit and mouse hippocampus]. [Zh Evol Biokhim Fiziol. 1982]
[Steroid-sensitive neurons of the rabbit and mouse hippocampus].
Belyĭ VP, Vorob'ev VS, Zakharov ND. Zh Evol Biokhim Fiziol. 1982 Mar-Apr; 18(2):161-4.
Effects of iontophoretically applied cortisol on tuberoinfundibular neurons in hypothalamic paraventricular nucleus of anesthetized rats. [Neurosci Lett. 1988]
Effects of iontophoretically applied cortisol on tuberoinfundibular neurons in hypothalamic paraventricular nucleus of anesthetized rats.
Kasai M, Kannan H, Ueta Y, Osaka T, Inenaga K, Yamashita H. Neurosci Lett. 1988 Apr 22; 87(1-2):35-40.
Modification of responses to sensory and hippocampal stimuli in neurons of the rat mediobasal hypothalamus in the presence of iontophoretically applied cortisol. [Brain Res. 1981]
Modification of responses to sensory and hippocampal stimuli in neurons of the rat mediobasal hypothalamus in the presence of iontophoretically applied cortisol.
Mandelbrod I, Feldman S, Werman R. Brain Res. 1981 Aug 10; 218(1-2):115-30.

See reviews... See all...

Cited by 2 PubMed Central articles

Review Corticosteroids: way upstream. [Mol Brain. 2010]
Review Corticosteroids: way upstream.
Riedemann T, Patchev AV, Cho K, Almeida OF. Mol Brain. 2010 Jan 11; 3:2. Epub 2010 Jan 11.
Mineralocorticoid receptor-mediated changes in membrane properties of rat CA1 pyramidal neurons in vitro. [Proc Natl Acad Sci U S A. 1990]
Mineralocorticoid receptor-mediated changes in membrane properties of rat CA1 pyramidal neurons in vitro.
Joëls M, de Kloet ER. Proc Natl Acad Sci U S A. 1990 Jun; 87(12):4495-8.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Iontophoretically applied corticosteroids do not affect the firing of hippocampa...
Iontophoretically applied corticosteroids do not affect the firing of hippocampal neurons.
Neuroendocrinology. 1977 ;23(4):248-56.

PubMed
Dose-response cocaine pharmacokinetics and metabolite profile following intraven...
Dose-response cocaine pharmacokinetics and metabolite profile following intravenous administration and arterial sampling in unanesthetized, freely moving male rats.
Neurotoxicol Teratol. 1997 Jan-Feb ;19(1):7-15.

PubMed
Rat hippocampal neurons in dispersed cell culture.
Rat hippocampal neurons in dispersed cell culture.
Brain Res. 1977 May 13 ;126(3):397-42.

PubMed
NMDA receptor antagonists impair prefrontal cortex function as assessed via spat...
NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine.
J Neurosci. 1996 Jan ;16(1):373-9.

PubMed
The effect of ovariectomy on the responsiveness of preoptic-septal neurons to mi...
The effect of ovariectomy on the responsiveness of preoptic-septal neurons to microelectrophoresed estrogen.
Neuroendocrinology. 1978 ;25(4):204-11.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: