Infect Immun. 1997 Mar;65(3):1098-100.

Humoral immune responses of Solomon Islanders to the merozoite surface antigen 2 of Plasmodium falciparum show pronounced skewing towards antibodies of the immunoglobulin G3 subclass.

Rzepczyk CM, Hale K, Woodroffe N, Bobogare A, Csurhes P, Ishii A, Ferrante A.

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Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Herston, Brisbane. christir@qimr.edu.au

Abstract

The immunoglobulin G (IgG) subclass distribution of antibodies to merozoite surface antigen 2 of Plasmodium falciparum in Solomon Islanders showed marked skewing towards the IgG3 subclass. This was not observed with crude P. falciparum schizont antigen. IgG3 responses may be short-lived and require repeated restimulation for their maintenance. This may be provided by persistent infection (premunition) or new infections.

PMID:: 9038322; [PubMed - indexed for MEDLINE]
PMCID:: PMC175094

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