Lancet. 1979 Sep 22;2(8143):606-9.

Hyponatraemic hypertensive syndrome with renal-artery occlusion corrected by captopril.

Atkinson AB, Davies DL, Leckie B, Morton JJ, Brown JJ, Fraser R, Lever AF, Robertson JI.

Abstract

Malignant hypertension with severe hyponatraemia, hypokalaemia, depletion of sodium and potassium, and elevated blood levels of renin, angiotensin I, angiotensin II, aldosterone, and arginine vasopressin developed in a woman with renal-artery occlusion. Plasma angiotensin II was disproportionately high in relation to exchangeable sodium. Captopril, by inhibiting conversion of angiotensin I to angiotensin II, further elevated the blood levels of renin and angiotensin I but corrected all other abnormalities. Unilateral nephrectomy was subsequently curative.

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Hyponatraemic hypertensive syndrome with renal-artery occlusion corrected by cap...
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Hyponatraemic hypertensive syndrome with renal-artery occlusion corrected by captopril.

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