Mol Gen Genet. 1977 May 20;153(1):111-3.

Inhibitors of mitochondrial function prevent senescence in the ascomycete Podosprora anserina.

Abstract

The onset of senescence, i.e. decrease of growth rate followed by cellular death, is prevented when inhibitors of mitochondrial function (ethidium-bromide, streptomycin, tiamulin) are present in the culture medium. If mycelia are transferred to a medium not containing one of these substances, senescence occurs after the usual time interval (30 d at 26 degrees C). Inhibitors of cytoplasmic protein synthesis such as emetine and cycloheximide have no effect in preventing senescence.

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Cited by 4 PubMed Central articles

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Inhibitors of mitochondrial function prevent senescence in the ascomycete Podosprora anserina.

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