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    Trends Biochem Sci. 1996 Sep;21(9):327-35.

    The role of general initiation factors in transcription by RNA polymerase II.

    Roeder RG.

    Source

    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, NY 10021, USA.

    Abstract

    Transcription initiation on protein-encoding genes represents a major control point for gene expression in eukaryotes, and is mediated by RNA polymerase II and a surprisingly complex array of general initiation factors (TFIIA, -B, -D, -E, -F and -H) that are highly conserved from yeast to man. Elucidation of structural and functional features of these factors on model promoters has revealed insights into biochemical mechanisms and provides a basis for understanding their regulation on diverse promoters by gene- and cell-specific activators.

    PMID:
    8870495
    [PubMed - indexed for MEDLINE]

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