Eur J Cancer. 1993;29A(8):1119-22.

Low-dose dopamine induces early recovery of recombinant interleukin-2--impaired renal function.

Palmieri G, Morabito A, Lauria R, Montesarchio V, Matano E, Memoli B, Libetta C, Rea A, Merola C, Correale P, et al.

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Cattedra di Oncologia Medica, II Facoltà di Medicina e Chirurgia, Università Federico II, Naples, Italy.

Abstract

Recombinant interleukin-2 (rIL-2) can produce impairment of renal function with hypotension, fluid retention, elevated blood urea nitrogen, oliguria and low fractional sodium excretion; these side-effects are a common cause of reduction or interruption of rIL-2 infusion. The aim of this study was to investigate the control and treatment of renal toxicity induced by rIL-2 therapy. Here we show that dopamine, at a low dose of 2 micrograms/kg/min, completely prevented renal toxicity induced by rIL-2. While continuing rIL-2 therapy, 24-h continuous infusion of low-dose dopamine produced a rapid normalisation of urine output and a significant decrease in serum creatinine levels and body weight (P < 0.01), with an early and complete recovery of the rIL-2--impaired renal function: mean recovery time of renal function in patients treated with dopamine was significantly lower (P < 0.05) than in nontreated patients (4.8 days vs. 10 days, respectively).

PMID:: 8518023; [PubMed - indexed for MEDLINE]

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Chemical compound information

Dopamine

MW: 153.17 g/mol

MF: C₈H₁₁NO₂

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