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    Nature. 1993 Jan 28;361(6410):315-25.

    Inositol trisphosphate and calcium signalling.

    Berridge MJ.

    Source

    AFRC Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK.

    Abstract

    Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels displays the regenerative process of calcium-induced calcium release responsible for the complex spatiotemporal patterns of calcium waves and oscillations. Such a dynamic signalling pathway controls many cellular processes, including fertilization, cell growth, transformation, secretion, smooth muscle contraction, sensory perception and neuronal signalling.

    PMID:
    8381210
    [PubMed - indexed for MEDLINE]

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