JAMA. 1976 Jun 28;235(26):2832-4.

Vaccine against human hepatitis B.

Buynak EB, Roehm RR, Tytell AA, Bertland AU 2nd, Lampson GP, Hilleman MR.

Abstract

A highly purified and inactivated vaccine was made of hepatitis B virus surface antigen. The vaccine was tested exhaustively for safety by ordinary procedures and additionally in chimpanzees and marmosets. It was highly potent and induced antibody in guinea pigs, grivet monkeys, and chimpanzees after three doses of vaccine were given subcutaneously. Chimpanzees given three doses of vaccine were protected against challenge with 1,000 chimpanzee-infectious doses of live human hepatitis B virus given intravenously in controlled studies. Tests of the vaccine for control of hepatitis B in man are to be carried out.

Comment in

JAMA. 2009 Jul 15;302(3):322-4.

PMID:: 819667; [PubMed - indexed for MEDLINE]

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Development and chimpanzee testing of a vaccine against human hepatitis B. [Proc Soc Exp Biol Med. 1976]
Development and chimpanzee testing of a vaccine against human hepatitis B.
Buynak EB, Roehm RR, Tytell AA, Bertland AU 2nd, Lampson GP, Hilleman MR. Proc Soc Exp Biol Med. 1976 Apr; 151(4):694-700.
Failure to detect infectious hepatitis B virus using high dose safety test for hepatitis B vaccine. [J Med Virol. 1981]
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Review Viral hepatitis: recent developments and prospects for prevention. [J Pediatr. 1975]
Review Viral hepatitis: recent developments and prospects for prevention.
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Vaccine against human hepatitis B.

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