Inflammation. 1994 Apr;18(2):119-27.

Nicotine-induced release of elastase and eicosanoids by human neutrophils.

Seow WK, Thong YH, Nelson RD, MacFarlane GD, Herzberg MC.

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Department of Dentistry, University of Queensland, Mater Childrens Hospital, South Brisbane, Australia.

Abstract

We examined the direct effects of nicotine on a variety of neutrophil functions at concentrations achievable in lung and oral tissues from cigarette smoking. The results show dose-dependent suppression of chemotaxis and phagocytosis, and enhancement of degranulation and eicosanoid generation, but not superoxide production. Cell viability was not affected by the concentrations of nicotine used in these experiments, as shown by trypan blue dye exclusion and MTT assays. These results implicate nicotine as the ingredient in cigarette smoke responsible for inflammatory damage to lungs and oral tissues observed in cigarette smokers.

PMID:: 8070897; [PubMed - indexed for MEDLINE]

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