Can J Comp Med. 1975 Apr;39(2):227-30.

Effect of penicillin on the humoral and cellular immune response following group A streptococcal pharyngitis.

Zimmerman RA, Klesius PH, Krushak DH, Mathews JH.

Abstract

The effect of oral and parenteral penicillin on the development of cellular and humoral immune responses in chimpanzees infected with group A streptococcal M-types 1, 5 and 12 was investigated. The interrelationship between type-specific antibody response and enhancement of phagocytic competence of polymorphonuclear neutrophils was documented. Penicillin depressed or suppressed type-specific antibody response depending on the mode and dose of administration, probably because of its effect on the streptococci responsible for antibody stimulation. Penicillin was not demonstrated to have a direct effect on phagocytic ability in vitro. Therefore the primary effect of antibiotic therapy is the indirect relationship to suppression or inhibition of type-specific antibody response to M-protein which results in a diminution of phagocytic competence.

PMID:: 804981; [PubMed - indexed for MEDLINE]
PMCID:: PMC1277446

Free PMC Article

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Unexplained reduced microbiological efficacy of intramuscular benzathine penicillin G and of oral penicillin V in eradication of group a streptococci from children with acute pharyngitis. [Pediatrics. 2001]
Unexplained reduced microbiological efficacy of intramuscular benzathine penicillin G and of oral penicillin V in eradication of group a streptococci from children with acute pharyngitis.
Kaplan EL, Johnson DR. Pediatrics. 2001 Nov; 108(5):1180-6.
Human streptococcal disease syndrome compared with observations in chimpanzees. II. Immunologic responses to induced pharyngitis and the effect of treatment. [J Infect Dis. 1970]
Human streptococcal disease syndrome compared with observations in chimpanzees. II. Immunologic responses to induced pharyngitis and the effect of treatment.
Zimmerman RA, Krushak DH, Wilson E, Douglas JD. J Infect Dis. 1970 Oct; 122(4):280-9.
Comparison of oral clindamycin to oral and intramuscular (benzathine) penicillin in the treatment of streptococcal pharyngitis. [Curr Ther Res Clin Exp. 1976]
Comparison of oral clindamycin to oral and intramuscular (benzathine) penicillin in the treatment of streptococcal pharyngitis.
Chernack WJ, Leidy G, Asnes RS, Grebin B, Sprunt K. Curr Ther Res Clin Exp. 1976 Jan; 19(1):11-9.
Review A half-century of streptococcal research: then & now. [Indian J Med Res. 2002]
Review A half-century of streptococcal research: then & now.
Krause RM. Indian J Med Res. 2002 Jun; 115:215-41.
Review Streptococcal pharyngitis in the 1980s. [Pediatr Infect Dis J. 1987]
Review Streptococcal pharyngitis in the 1980s.
Dillon HC Jr. Pediatr Infect Dis J. 1987 Jan; 6(1):123-30.

See reviews... See all...

Cited by 1 PubMed Central article

Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus. [BMC Microbiol. 2009]
Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus.
Zimecki M, Artym J, Kocieba M, Weber-Dabrowska B, Borysowski J, Górski A. BMC Microbiol. 2009 Aug 17; 9:169. Epub 2009 Aug 17.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Effect of penicillin on the humoral and cellular immune response following group...
Effect of penicillin on the humoral and cellular immune response following group A streptococcal pharyngitis.
Can J Comp Med. 1975 Apr ;39(2):227-30.

PubMed
HLA-DRB1 alleles as severity markers in RA.
HLA-DRB1 alleles as severity markers in RA.
Bull Rheum Dis. 1994 Jun ;43(4):5-8.

PubMed
Inverted repetitious sequences in the macronuclear DNA of hypotrichous ciliates.
Inverted repetitious sequences in the macronuclear DNA of hypotrichous ciliates.
Proc Natl Acad Sci U S A. 1975 Feb ;72(2):678-82.

PubMed
Crystallization and structure determination of bovine profilin at 2.0 A resoluti...
Crystallization and structure determination of bovine profilin at 2.0 A resolution.
J Mol Biol. 1994 Jul 29 ;240(5):459-75.

PubMed
Amphetamine stereotypy: the influence of environmental factors and prepotent beh...
Amphetamine stereotypy: the influence of environmental factors and prepotent behavioral patterns on its topography and development.
Biol Psychiatry. 1975 Feb ;10(1):3-16.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Effect of penicillin on the humoral and cellular immune response following group A streptococcal pharyngitis.

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information