Clin Exp Immunol. 1995 May;100(2):198-204.

Autoantibodies against eukaryotic protein L7 in patients suffering from systemic lupus erythematosus and progressive systemic sclerosis: frequency and correlation with clinical, serological and genetic parameters. The SLE Study Group.

Neu E, von Mikecz AH, Hemmerich PH, Peter HH, Fricke M, Deicher H, Genth E, Krawinkel U.

Source

Lehrstuhl für Immunologie, Fakultät für Biologie, Universität Konstanz, Freiburg, Germany.

Abstract

Recent studies have shown that sera of patients suffering from systemic autoimmune diseases contain autoantibodies directed against the eukaryotic ribosomal protein L7 [1]. In the present study we screened a large panel of sera from patients with systemic lupus erythematosus (SLE) for the presence of anti-L7 autoantibodies and their relationship to clinical, serological and genetic parameters of SLE. By means of an ELISA employing recombinant protein L7 as antigen we detected anti-L7 autoantobodies in 172 of 506 SLE sera (34%). Negative correlations were observed between the presence of anti-L7 autoantibodies, serum IgG levels and proteinuria; a potentially positive relationship existed with lung fibrosis. In order to analyse further this possibility we screened sera of 129 patients suffering from progressive systemic sclerosis (PSS) for anti-L7 reactivity; 45 of these patients had lung fibrosis. Of the PSS patients, 41% exhibited anti-L7 autoantibodies, but positive reactions were evenly distributed among patients with and without lung fibrosis. Protein L7 thus represents a major autoantigen of systemic autoimmune diseases, but does not so far define a distinct subpopulation of patients.

PMID:: 7743655; [PubMed - indexed for MEDLINE]
PMCID: PMC1534346

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Characterization of eukaryotic protein L7 as a novel autoantigen which frequently elicits an immune response in patients suffering from systemic autoimmune disease. [Immunobiology. 1994]
Characterization of eukaryotic protein L7 as a novel autoantigen which frequently elicits an immune response in patients suffering from systemic autoimmune disease.
von Mikecz A, Hemmerich P, Peter HH, Krawinkel U. Immunobiology. 1994 Dec; 192(1-2):137-54.
Characteristic epitope recognition pattern of autoantibodies against eukaryotic ribosomal protein L7 in systemic autoimmune diseases. [Arthritis Rheum. 1997]
Characteristic epitope recognition pattern of autoantibodies against eukaryotic ribosomal protein L7 in systemic autoimmune diseases.
Neu E, Hemmerich PH, Peter HH, Krawinkel U, von Mikecz AH. Arthritis Rheum. 1997 Apr; 40(4):661-71.
Autoantibodies to the translational suppressors T cell intracytoplasmic antigen 1 and T cell intracytoplasmic antigen 1-related protein in patients with rheumatic diseases: increased prevalence in systemic lupus erythematosus and systemic sclerosis and correlation with clinical features. [Arthritis Rheum. 2008]
Autoantibodies to the translational suppressors T cell intracytoplasmic antigen 1 and T cell intracytoplasmic antigen 1-related protein in patients with rheumatic diseases: increased prevalence in systemic lupus erythematosus and systemic sclerosis and correlation with clinical features.
Jimenez-Boj E, Kedersha N, Tohidast-Akrad M, Karlhofer FM, Stummvoll G, Zimmermann C, Ulrich W, Guiducci S, Hoefler E, Aringer M, et al. Arthritis Rheum. 2008 May; 58(5):1226-36.
Review Antiribosomal antibodies in SLE, infection, and following deliberate immunization. [Adv Exp Med Biol. 1994]
Review Antiribosomal antibodies in SLE, infection, and following deliberate immunization.
Elkon KB, Bonfa E, Weissbach H, Brot N. Adv Exp Med Biol. 1994; 347:81-92.
Review Are anti-ribosomal P protein antibodies relevant in systemic lupus erythematosus? [Clin Rev Allergy Immunol. 2007]
Review Are anti-ribosomal P protein antibodies relevant in systemic lupus erythematosus?
Kiss E, Shoenfeld Y. Clin Rev Allergy Immunol. 2007 Feb; 32(1):37-46.

See reviews... See all...

Cited by 2 PubMed Central articles

A web tool for finding gene candidates associated with experimentally induced arthritis in the rat. [Arthritis Res Ther. 2005]
A web tool for finding gene candidates associated with experimentally induced arthritis in the rat.
Andersson L, Petersen G, Johnson P, Ståhl F. Arthritis Res Ther. 2005; 7(3):R485-92. Epub 2005 Feb 18.
Screening of a HUVEC cDNA library with transplant-associated coronary artery disease sera identifies RPL7 as a candidate autoantigen associated with this disease. [Clin Exp Immunol. 2001]
Screening of a HUVEC cDNA library with transplant-associated coronary artery disease sera identifies RPL7 as a candidate autoantigen associated with this disease.
Linke AT, Marchant B, Marsh P, Frampton G, Murphy J, Rose ML. Clin Exp Immunol. 2001 Oct; 126(1):173-9.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Autoantibodies against eukaryotic protein L7 in patients suffering from systemic...
Autoantibodies against eukaryotic protein L7 in patients suffering from systemic lupus erythematosus and progressive systemic sclerosis: frequency and correlation with clinical, serological and genetic parameters. The SLE Study Group.
Clin Exp Immunol. 1995 May ;100(2):198-204.

PubMed
Induction of autoimmune arthritis in HLA-DR4 (DRB1*0401) transgenic mice by immu...
Induction of autoimmune arthritis in HLA-DR4 (DRB1*0401) transgenic mice by immunization with human and bovine type II collagen.
J Immunol. 1998 Mar 15 ;160(6):2573-8.

PubMed
Use of dynamic magnetic resonance imaging with fast imaging in the detection of ...
Use of dynamic magnetic resonance imaging with fast imaging in the detection of early and advanced sacroiliitis in spondylarthropathy patients.
Arthritis Rheum. 1994 Jul ;37(7):1039-45.

PubMed
The effects of gender and sex hormones on outcome in rheumatoid arthritis.
The effects of gender and sex hormones on outcome in rheumatoid arthritis.
Baillieres Clin Rheumatol. 1992 Feb ;6(1):196-219.

PubMed
Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.
Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.
Proc Natl Acad Sci U S A. 1993 Dec 15 ;90(24):11924-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: