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    Nature. 1993 Mar 4;362(6415):31-8.

    Cloning and expression of an inwardly rectifying ATP-regulated potassium channel.

    Ho K, Nichols CG, Lederer WJ, Lytton J, Vassilev PM, Kanazirska MV, Hebert SC.

    Source

    Harvard Center for the Study of Kidney Disease, Harvard Medical School, Boston, Massachusetts.

    Abstract

    A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney. The predicted 45K protein, which features two potential membrane-spanning helices and a proposed ATP-binding domain, represents a major departure from the basic structural design characteristic of voltage-gated and second messenger-gated ion channels. But the presence of an H5 region, which is likely to form the ion conduction pathway, indicates that the protein may share a common origin with voltage-gated potassium channel proteins.

    PMID:
    7680431
    [PubMed - indexed for MEDLINE]

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