J Chromatogr. 1979 Feb 21;162(2):153-61.

Surfactant ion-pair high-performance liquid chromatography of tryptophan and some of its metabolites in biological fluids.

Riley CM, Tomlinson E, Jefferies TM, Redfern PH.

Abstract

A rapid, sensitive assay for tryptophan and some of its metabolites in urine, plasma and saliva has been developed using sodium dodecylsulphate as a pairing ion in a surfactant ion-pair high-performance liquid chromatography technique. The method is highly selective for tryptophan which is separated from its main indoleamine metabolites, 5-hydroxytryptophan, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid, and from kynurenine. The usefulness of the assay has been demonstrated in plasma level and urinary excretion studies of orally administered tryptophan.

PMID:: 762217; [PubMed - indexed for MEDLINE]

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Tryptophan

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