Lancet. 1978 Jan 28;1(8057):185-7.

Persistence of drug-resistant malaria parasites.

Rosario VE, Hall R, Walliker D, Beale GH.

Abstract

Mixtures of drug-resistant and sensitive forms of Plasmodium chabaudi were used to infect mice, and the resulting infections were maintained in the absence of drug. Both chloroquine-resistant and pyrimethamine-resistant mutans were able to survive in such mixed infections. The results of experiments on chloroquine resistance indicated an apparent selective advantage of the resistant over the sensitive form.

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