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    Am J Psychiatry. 1978 Sep;135(9):1070-8.

    A heritable disorder of lithium transport in erythrocytes of a subpopulation of manic-depressive patients.

    Ostrow DG, Pandey GN, Davis JM, Hurt SW, Tosteson DC.

    Abstract

    The in vivo RBC/plasma Li+ ratio is determined by the equilibrium between Li+ influx (ouabain-sensitive Na+-K+ pump and ouabain-insensitive leakage pathways) and Li+ efflux (phloretin-sensitive Li+-Na+ counterflow). A study of RBC Li+ transport via these pathways showed that a deficiency of Li+-Na+ counterflow was responsible for the high in vivo ratio (1:1) observed in a manic patient. This defect was related to an alteration in the membrane Na+ exchange system and was under genetic control. The level of counterflow before lithium therapy was an excellent predictor (r = .88) of the in vivo Li+ ratio and was deficient in approximately one-fourth of manic-depressive patients but not in controls, schizophrenics, or unipolar depressed patients.

    PMID:
    696928
    [PubMed - indexed for MEDLINE]

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