Kidney Int. 1978 Aug;14(2):187-90.

Norepinephrine-induced acute renal failure: a reversible ischemic model of acute renal failure.

Cronin RE, Erickson AM, de Torrente A, McDonald KM, Schrier RW.

Abstract

The present study has defined conditions whereby a reversible form of ischemia-induced ARF can be produced in the dog. Unlike previous studies [9-11] which examined the acute phase of NE-induced ARF, this study demonstrates the feasibility of using the model for the longitudinal study of ARF. Such a model may be useful in studying the pathologic and physiologic changes which occur during different phases of ARF. Perhaps most important, this model should also provide a setting in which treatment measures, either prophylactic or therapeutic for ARF, can be examined.

PMID:: 691976; [PubMed - indexed for MEDLINE]

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