J Exp Med. 1980 Sep 1;152(3):742-7.

Detection of active kallikrein in induced blister fluids of hereditary angioedema patients.

Abstract

Six suction-induced blister fluids obtained from five patients with hereditary angioedema (HAE) contained active kallikrein, whereas only two blister fluids obtained from eight normal volunteers contained small amounts of this activity. Kallikrein was present in large amounts of HAE blister fluids as assessed by its ability to liberate smooth-muscle-contracting activity from purified high molecular weight kininogen. It was inhibited by purified antibodies specific for plasma prekallikrein and also by purified C1 inhibitor, but not by antibodies specific for C1s. These observations suggest that activation of the Hageman-factor-dependent pathways occurs in the tissues of HAE patients, and once generated, active kallikrein persists in these tissues.

PMID:: 6902743; [PubMed - indexed for MEDLINE]
PMCID:: PMC2185921

Free PMC Article

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Edema - MedlinePlus Health Information

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Hageman factor-dependent pathways: mechanism of initiation and bradykinin formation. [Fed Proc. 1983]
Hageman factor-dependent pathways: mechanism of initiation and bradykinin formation.
Kaplan AP. Fed Proc. 1983 Nov; 42(14):3123-7.
Pathways of kinin formation and role in allergic diseases. [Clin Immunol Immunopathol. 1989]
Pathways of kinin formation and role in allergic diseases.
Kaplan AP, Silverberg M, Ghebrehiwet B, Atkins P, Zweiman B. Clin Immunol Immunopathol. 1989 Jan; 50(1 Pt 2):S41-51.
Review The bradykinin-forming cascade and its role in hereditary angioedema. [Ann Allergy Asthma Immunol. 2010]
Review The bradykinin-forming cascade and its role in hereditary angioedema.
Kaplan AP, Joseph K. Ann Allergy Asthma Immunol. 2010 Mar; 104(3):193-204.
Interactions of plasma kallikrein and C1-s with normal and dysfunctional C1(-)-inhibitor proteins from patients with hereditary angioneurotic edema: analytic gel studies. [Blood. 1987]
Interactions of plasma kallikrein and C1-s with normal and dysfunctional C1(-)-inhibitor proteins from patients with hereditary angioneurotic edema: analytic gel studies.
Donaldson VH, Wagner CJ, Tsuei B, Kindness G, Bing DH, Harrison RA, Rosen FS. Blood. 1987 Apr; 69(4):1096-101.
Review Enzymatic pathways in the pathogenesis of hereditary angioedema: the role of C1 inhibitor therapy. [J Allergy Clin Immunol. 2010]
Review Enzymatic pathways in the pathogenesis of hereditary angioedema: the role of C1 inhibitor therapy.
Kaplan AP. J Allergy Clin Immunol. 2010 Nov; 126(5):918-25.

See reviews... See all...

Cited by 10 PubMed Central articles

HAE therapies: past present and future. [Allergy Asthma Clin Immunol. 2...]
HAE therapies: past present and future.
Zuraw BL. Allergy Asthma Clin Immunol. 2010 Jul 28; 6(1):23. Epub 2010 Jul 28.
Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation. [J Clin Invest. 2008]
Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation.
Maas C, Govers-Riemslag JW, Bouma B, Schiks B, Hazenberg BP, Lokhorst HM, Hammarström P, ten Cate H, de Groot PG, Bouma BN, et al. J Clin Invest. 2008 Sep; 118(9):3208-18.
Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. [J Clin Invest. 2002]
Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor.
Han ED, MacFarlane RC, Mulligan AN, Scafidi J, Davis AE 3rd. J Clin Invest. 2002 Apr; 109(8):1057-63.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Detection of active kallikrein in induced blister fluids of hereditary angioedem...
Detection of active kallikrein in induced blister fluids of hereditary angioedema patients.
J Exp Med. 1980 Sep 1 ;152(3):742-7.

PubMed
Letter: IgE, parasites, and allergy.
Letter: IgE, parasites, and allergy.
Lancet. 1976 Sep 25 ;2(7987):686.

PubMed
Acquired C1 inhibitor deficiency in a case of lymphosarcoma of the spleen. Rever...
Acquired C1 inhibitor deficiency in a case of lymphosarcoma of the spleen. Reversal of complement abnormalities after splenectomy.
Clin Exp Immunol. 1979 Sep ;37(3):523-31.

PubMed
Permeability-increasing activity in hereditary angioneurotic edema plasma. II. M...
Permeability-increasing activity in hereditary angioneurotic edema plasma. II. Mechanism of formation and partial characterization.
J Clin Invest. 1969 Apr ;48(4):642-53.

PubMed
Exercise-induced anaphylactic reaction to shellfish.
Exercise-induced anaphylactic reaction to shellfish.
J Allergy Clin Immunol. 1979 Jun ;63(6):433-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: