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    Nature. 1982 Jul 29;298(5873):447-51.

    Homology among DNA-binding proteins suggests use of a conserved super-secondary structure.

    Abstract

    The amino acid sequences of the repressor and cro proteins of phages lambda, 434 and P22 are homologous, especially in a region in which repressor and lambda cro have a similar alpha-helix-turn-alpha-helix secondary structure. Model-building studies indicate that this structure is important in DNA binding, and we suggest it may be a common feature of many DNa-binding proteins.

    PMID:
    6896364
    [PubMed - indexed for MEDLINE]

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