Genetics. 1983 Jul;104(3):449-56.

Evidence for balancing selection at HLA.

Abstract

HLA data from the A and B loci for 22 populations were compared with the neutrality expectations from Ewens' sampling theory. In 25 of 44 cases, there was significantly less homozygosity than expected. Although a number of factors can affect homozygosity in this manner, upon close examination only symmetrical balancing selection appears to be consistent with these data.

PMID:: 6884768; [PubMed - indexed for MEDLINE]
PMCID:: PMC1202087

Free PMC Article

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

HLA Antigens

Grant Support

R01 HD 12731/HD/NICHD NIH HHS/United States

LinkOut - more resources

Full Text Sources

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

HLA polymorphism in the Havasupai: evidence for balancing selection. [Am J Hum Genet. 1993]
HLA polymorphism in the Havasupai: evidence for balancing selection.
Markow T, Hedrick PW, Zuerlein K, Danilovs J, Martin J, Vyvial T, Armstrong C. Am J Hum Genet. 1993 Oct; 53(4):943-52.
Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci. [Tissue Antigens. 2004]
Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci.
Cao K, Moormann AM, Lyke KE, Masaberg C, Sumba OP, Doumbo OK, Koech D, Lancaster A, Nelson M, Meyer D, et al. Tissue Antigens. 2004 Apr; 63(4):293-325.
Signatures of demographic history and natural selection in the human major histocompatibility complex Loci. [Genetics. 2006]
Signatures of demographic history and natural selection in the human major histocompatibility complex Loci.
Meyer D, Single RM, Mack SJ, Erlich HA, Thomson G. Genetics. 2006 Aug; 173(4):2121-42. Epub 2006 May 15.
Review The evolution of major histocompatibility class I genes in primates. [Crit Rev Immunol. 1995]
Review The evolution of major histocompatibility class I genes in primates.
Watkins DI. Crit Rev Immunol. 1995; 15(1):1-29.
Review HLA, aging, and longevity: a critical reappraisal. [Hum Immunol. 2000]
Review HLA, aging, and longevity: a critical reappraisal.
Caruso C, Candore G, Colonna Romano G, Lio D, Bonafè M, Valensin S, Franceschi C. Hum Immunol. 2000 Sep; 61(9):942-9.

See reviews... See all...

Cited by 34 PubMed Central articles

Variation in MHC genotypes in two populations of house sparrow (Passer domesticus) with different population histories. [Ecol Evol. 2011]
Variation in MHC genotypes in two populations of house sparrow (Passer domesticus) with different population histories.
Borg AA, Pedersen SA, Jensen H, Westerdahl H. Ecol Evol. 2011 Oct; 1(2):145-59.
Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection. [Am J Hum Genet. 2011]
Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection.
Bhatia G, Patterson N, Pasaniuc B, Zaitlen N, Genovese G, Pollack S, Mallick S, Myers S, Tandon A, Spencer C, et al. Am J Hum Genet. 2011 Sep 9; 89(3):368-81.
Frequency distribution of HLA DQ2 and DQ8 in celiac patients and first-degree relatives in Recife, northeastern Brazil. [Clinics (Sao Paulo). 2011]
Frequency distribution of HLA DQ2 and DQ8 in celiac patients and first-degree relatives in Recife, northeastern Brazil.
Castro-Antunes MM, Crovella S, Brandão LA, Guimaraes RL, Motta ME, Silva GA. Clinics (Sao Paulo). 2011; 66(2):227-31.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Evidence for balancing selection at HLA.
Evidence for balancing selection at HLA.
Genetics. 1983 Jul ;104(3):449-56.

PubMed
The metabolism of carbohydrates by extremely halophilic bacteria: the identifica...
The metabolism of carbohydrates by extremely halophilic bacteria: the identification of lactobionic acid as a product of lactose metabolism by Halobacterium saccharovorum.
Can J Microbiol. 1978 Aug ;24(8):898-903.

PubMed
The hospital anxiety and depression scale.
The hospital anxiety and depression scale.
Acta Psychiatr Scand. 1983 Jun ;67(6):361-70.

PubMed
Ultrastructure, karyology and immunology of a cell line originated from a human ...
Ultrastructure, karyology and immunology of a cell line originated from a human transitional-cell carcinoma.
Br J Cancer. 1978 Jul ;38(1):64-76.

PubMed
Age as a predictor of treatment response in endogenous depression.
Age as a predictor of treatment response in endogenous depression.
J Clin Psychopharmacol. 1983 Jun ;3(3):176-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: