Science. 1983 Feb 25;219(4587):983-5.

Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.

Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF.

Abstract

Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors.

PMID:: 6823562; [PubMed - indexed for MEDLINE]

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