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    Comput Programs Biomed. 1984;18(3):173-9.

    Planning a clinical trial with allowance for cost and patient recruitment rate.

    Abstract

    This paper deals with: (1) estimation of the optimum clinical trial size minimizing the total cost, given types I and II errors, alpha, beta and response rate difference, delta; (2) studying the test performance by calculating the operating characteristic curve in case of available fixed total cost; (3) mapping the future course of the patient recruitment plan by estimating recruitment rate and final intake based on enrollment to date; (4) projecting the recruitment duration and probability of achieving the contracted goal in case the recruitment rate is well established.

    PMID:
    6548679
    [PubMed - indexed for MEDLINE]

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