J Infect Dis. 1978 Apr;137(4):437-42.

Inactivation of penicillin G during experimental infection with Bacteroides fragilis.

O'Keefe JP, Tally FP, Barza M, Gorbach SL.

Abstract

An animal model implanted with intraperitoneal plastic reservoirs was used for study of the penetration of penicillin G into sites infected with Bacteroides fragilis. Penicillin G was given to rabbits, and its concentration in uninfected reservoirs and in those infected with B. fragilis was determined. The mean percentage penetration ([concentration in capsule divided by peak concentration in serum] X 100) of penicillin into uninfected capsules was 19.9%, whereas that into heavily infected capsules was 1.5%. The percentage penetration of radiolabeled penicillin into infected capsules was 12.5%, whereas the proportion of bioactive drug in the same capsules was again very low (1%). These results show that there is a modest reduction in penetration of penicillin into infected sites and a striking inactivation of the drug by B. fragilis in this experimental model.

PMID:: 649987; [PubMed - indexed for MEDLINE]

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Penicillin G

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